March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Retinal Blood Flow In Healthy Young Subjects
Author Affiliations & Notes
  • Gerhard Garhofer
    Department of Clinical Pharmacology,
    Medical University of Vienna, Vienna, Austria
  • Rene M. Werkmeister
    Biomed Engineering & Physics,
    Medical University of Vienna, Vienna, Austria
  • Nikolaus Dragostinoff
    Biomed Engineering & Physics,
    Medical University of Vienna, Vienna, Austria
  • Leopold Schmetterer
    Department of Clinical Pharmacology,
    Biomed Engineering & Physics,
    Medical University of Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships  Gerhard Garhofer, None; Rene M. Werkmeister, None; Nikolaus Dragostinoff, None; Leopold Schmetterer, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 6833. doi:
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    • Get Citation

      Gerhard Garhofer, Rene M. Werkmeister, Nikolaus Dragostinoff, Leopold Schmetterer; Retinal Blood Flow In Healthy Young Subjects. Invest. Ophthalmol. Vis. Sci. 2012;53(14):6833.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To characterize total retinal blood flow in a group of healthy subjects.

Methods: : 64 healthy volunteers were included in this study. Retinal venous diameters were measured using a Dynamic Vessel Analyzer (DVA). Retinal blood velocities were measured using bi-directional laser Doppler velocimetry (LDV). All vessels with a diameter of more than 60 µm entering the optic nerve head were measured. Total retinal blood flow was measured by summing up all data from the individually measured vessels. In a subgroup of 10 healthy subjects measurements were also taken from the arteries, and results obtained for total retinal blood flow as measured from retinal veins as well as from retinal arteries were compared.

Results: : Total retinal blood flow was 44.0 ± 13.3 µl/min. Retinal blood flow was highest in the temporal inferior quadrant, followed by the temporal superior quadrant, the nasal inferior quadrant and the nasal superior quadrant (p < 0.001 each). In all quadrants retinal blood velocities were linearly correlated to vessel diameters. Retinal blood flow as measured in retinal veins (42.1 ± 13.0 µl/min) and retinal arteries (42.1 ± 12.1 µl/min) was similar (p = 0.16).

Conclusions: : The present study provides reference values for total retinal blood flow in 64 healthy subjects. The inter-individual variability in retinal blood flow is high, making it unlikely that individual diagnostics can be based on measurements of retinal blood flow. Total retinal blood flow may, however, be important in risk stratification, which needs to be proven in future studies.

Keywords: retina • blood supply 
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