March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Assessment of Oxygen Saturation in Retinal Vessels of Normal Subjects and Diabetic Patients without Retinopathy using the Johns Hopkins Flow Oximetry System
Author Affiliations & Notes
  • Rachel E. Annam
    Johns Hopkins University, Wilmer Eye Institute, Baltimore, Maryland
  • Mohamed A. Ibrahim
    Johns Hopkins University, Wilmer Eye Institute, Baltimore, Maryland
  • Long Luu
    Biomedical Engineering, Catholic University of America, Washington, Dist. of Columbia
  • Yasir J. Sepah
    Johns Hopkins University, Wilmer Eye Institute, Baltimore, Maryland
  • Millena G. Bittencourt
    Johns Hopkins University, Wilmer Eye Institute, Baltimore, Maryland
  • Owhofasa Agbedia
    Johns Hopkins University, Wilmer Eye Institute, Baltimore, Maryland
  • Hyun S. Jang
    Johns Hopkins University, Wilmer Eye Institute, Baltimore, Maryland
  • Jithin Yohannan
    Johns Hopkins University, Wilmer Eye Institute, Baltimore, Maryland
  • Jessica Ramella-Roman
    Biomedical Engineering, Catholic University of America, Washington, Dist. of Columbia
  • Quan D. Nguyen
    Diseases of the Retina, and Uveitis, Johns Hopkins Univ,Wilmer Eye Inst, Baltimore, Maryland
  • Footnotes
    Commercial Relationships  Rachel E. Annam, None; Mohamed A. Ibrahim, None; Long Luu, None; Yasir J. Sepah, None; Millena G. Bittencourt, None; Owhofasa Agbedia, None; Hyun S. Jang, None; Jithin Yohannan, None; Jessica Ramella-Roman, None; Quan D. Nguyen, None
  • Footnotes
    Support  National Eye Institute RO1 Award (EY17577)
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 6838. doi:
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      Rachel E. Annam, Mohamed A. Ibrahim, Long Luu, Yasir J. Sepah, Millena G. Bittencourt, Owhofasa Agbedia, Hyun S. Jang, Jithin Yohannan, Jessica Ramella-Roman, Quan D. Nguyen; Assessment of Oxygen Saturation in Retinal Vessels of Normal Subjects and Diabetic Patients without Retinopathy using the Johns Hopkins Flow Oximetry System. Invest. Ophthalmol. Vis. Sci. 2012;53(14):6838.

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Abstract

Purpose: : To determine oxygen saturation (SO2) in retinal vessels of normal subjects and diabetic patients without retinopathy using the Johns Hopkins Flow Oximetry System (JHFOS) with novel assessment software and to establish a range of normal retinal oxygen saturation in the venous circulation and analyze the differences across the study groups.

Methods: : The novel assessment software was used to determine oxygen saturation levels in veins located between 1 to 2 mm from the margin of the optic disc in normal subjects and diabetic patients without retinopathy employing images captured by JHFOS. The retina was divided into 4 quadrants (superior, inferior, temporal, and nasal), although the majority of vessels were in the superior and inferior quadrants. Only those vessels clearly identified as veins by the ophthalmologists were included in the analysis.

Results: : 21 normal subjects (12 females and 9 males, mean age = 56 years) contributed 21 eyes, and 17 diabetic patients (8 females and 9 males, mean age = 61 years) contributed 17 eyes to the final analysis. The mean (+/-SD) SO2 in retinal veins of normal subjects was 55.2 ± 6.6% (95% CI 52.2 - 58.2) and the mean (+/-SD) venous SO2 in diabetic patients without retinopathy was 59.6 ± 10.4% (95% CI 54.3 - 64.9).

Conclusions: : A range of normal venous SO2 has been established using the JHFOS.The mean venous SO2 was found to be higher in diabetic patients without retinopathy compared with normal subjects. The results obtained from the JHFOS are in agreement with previously published data. Further studies with additional subjects are indicated to validate the use of JHFOS in detecting retinal oxygenation as well as to assess levels of retinal oxygenation among normal subjects and diabetics with different stages of retinopathy.

Keywords: diabetes • imaging/image analysis: clinical • oxygen 
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