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Inge H. Bronkhorst, T.H. Khanh Vu, Ekaterina S. Jordanova, Gregorius P. Luyten, Sjoerd H. van der Burg, Martine J. Jager; Different Subsets Of Tumor-infiltrating Lymphocytes Correlate With Macrophage Influx And Monosomy 3 In Uveal Melanoma. Invest. Ophthalmol. Vis. Sci. 2012;53(14):6902.
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In contrast to many other malignancies, in uveal melanoma, the presence of an immune infiltrate is associated with a bad prognosis. An analysis of the different functional phenotypes of tumor-infiltrating leukocytes (TIL) and a comparison with the genetic background of the tumors may help explain this unusual situation.
We performed a comprehensive immunohistochemical study by evaluating the density of CD8+ and CD4+ T lymphocytes, Foxp3+ regulatory T cells (Tregs), CD68+ and CD68+CD163+ macrophages in 43 cases of uveal melanoma. The presence of these different TILs was compared to tumor characteristics.
The presence of TILs varied greatly between tumors, with among the T cells a predominance of CD8+ T cells, and fewer CD4+ T cells and Tregs. The different subsets of tumor-infiltrating lymphocytes were significantly correlated with each other as well as with the density of M2 macrophages (Spearman correlation coefficient = 0.81), and with the presence of monosomy 3.
As the numbers of different lymphocytic and myeloid cell types were associated with loss of one chromosome 3, tumor-intrinsic factors probably control the influx of TIL. Their presence may contribute to the increased malignancy seen in high risk uveal melanoma cases.
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