April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Involvement of Matrix Metalloproteinases 7 in Differentiation of Retinoblastoma cell
Hyun Beom Song; Dong Hyun Jo; Jin Hyoung Kim; Young Suk Yu; Jeong Hun Kim
Author Affiliations & Notes
  • Hyun Beom Song
    Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Department of Ophthalmology, College of Medicine, Seoul National University & Seoul Artificial Eye Center Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
  • Dong Hyun Jo
    Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Department of Ophthalmology, College of Medicine, Seoul National University & Seoul Artificial Eye Center Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
  • Jin Hyoung Kim
    Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Department of Ophthalmology, College of Medicine, Seoul National University & Seoul Artificial Eye Center Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
  • Young Suk Yu
    Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Department of Ophthalmology, College of Medicine, Seoul National University & Seoul Artificial Eye Center Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
  • Jeong Hun Kim
    Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Department of Ophthalmology, College of Medicine, Seoul National University & Seoul Artificial Eye Center Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships  Hyun Beom Song, None; Dong Hyun Jo, None; Jin Hyoung Kim, None; Young Suk Yu, None; Jeong Hun Kim, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 2479. doi:
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      Hyun Beom Song, Dong Hyun Jo, Jin Hyoung Kim, Young Suk Yu, Jeong Hun Kim; Involvement of Matrix Metalloproteinases 7 in Differentiation of Retinoblastoma cell. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2479.

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Abstract

Purpose: : The aim of this study is to investigate the expression of matrix metalloproteinase 7 (MMP-7) in retinoblastoma tissue.

Methods: : To determine the localization of MMP-7, immunohistochemistry was performed on mouse retinoblastoma tissues of SNUOT-Rb1 and Y79. TrkA and TrkB were used as a differentiation marker and a proliferation marker respectively.

Results: : MMP-7 was found to be co-localized with TrkA rather than TrkB, but the pattern of expression was slightly different. TrkA was more strongly expressed where nuclear-cytoplasmic ratio (NC ratio) was high, but MMP-7 was more strongly expressed where NC ratio was low. The certain part of SNUOT-Rb1 tissue was showing strong expression of MMP-7 with relatively weak expression of TrkA.

Conclusions: : The expression of MMP-7 is closely related to differentiation, but the patterns are different between tissues with different cell lines.

Keywords: retinoblastoma 
© 2011, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2015 Association for Research in Vision and Ophthalmology.
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