April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Involvement of Matrix Metalloproteinases 7 in Differentiation of Retinoblastoma cell
Author Affiliations & Notes
  • Hyun Beom Song
    Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Department of Ophthalmology, College of Medicine, Seoul National University & Seoul Artificial Eye Center Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
  • Dong Hyun Jo
    Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Department of Ophthalmology, College of Medicine, Seoul National University & Seoul Artificial Eye Center Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
  • Jin Hyoung Kim
    Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Department of Ophthalmology, College of Medicine, Seoul National University & Seoul Artificial Eye Center Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
  • Young Suk Yu
    Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Department of Ophthalmology, College of Medicine, Seoul National University & Seoul Artificial Eye Center Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
  • Jeong Hun Kim
    Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Department of Ophthalmology, College of Medicine, Seoul National University & Seoul Artificial Eye Center Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships  Hyun Beom Song, None; Dong Hyun Jo, None; Jin Hyoung Kim, None; Young Suk Yu, None; Jeong Hun Kim, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 2479. doi:
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      Hyun Beom Song, Dong Hyun Jo, Jin Hyoung Kim, Young Suk Yu, Jeong Hun Kim; Involvement of Matrix Metalloproteinases 7 in Differentiation of Retinoblastoma cell. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2479.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : The aim of this study is to investigate the expression of matrix metalloproteinase 7 (MMP-7) in retinoblastoma tissue.

Methods: : To determine the localization of MMP-7, immunohistochemistry was performed on mouse retinoblastoma tissues of SNUOT-Rb1 and Y79. TrkA and TrkB were used as a differentiation marker and a proliferation marker respectively.

Results: : MMP-7 was found to be co-localized with TrkA rather than TrkB, but the pattern of expression was slightly different. TrkA was more strongly expressed where nuclear-cytoplasmic ratio (NC ratio) was high, but MMP-7 was more strongly expressed where NC ratio was low. The certain part of SNUOT-Rb1 tissue was showing strong expression of MMP-7 with relatively weak expression of TrkA.

Conclusions: : The expression of MMP-7 is closely related to differentiation, but the patterns are different between tissues with different cell lines.

Keywords: retinoblastoma 
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