April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Comparison of an Automated Method for Volumetric Quantification of Papilledema with the Frisén Scale
Author Affiliations & Notes
  • Jui-Kai Wang
    Electrical and Computer Engineering,
    University of Iowa, Iowa City, Iowa
  • Randy H. Kardon
    Ophthalmology and Visual Sciences,
    University of Iowa, Iowa City, Iowa
    Veterans Administration Hospital, Iowa City, Iowa
  • Bhavna J. Antony
    Electrical and Computer Engineering,
    University of Iowa, Iowa City, Iowa
  • Mark J. Kupersmith
    Neuro-Ophthalmology, Roosevelt Hospital and NYEE, New York, New York
  • Mona K. Garvin
    Electrical and Computer Engineering,
    University of Iowa, Iowa City, Iowa
    Veterans Administration Hospital, Iowa City, Iowa
  • Footnotes
    Commercial Relationships  Jui-Kai Wang, None; Randy H. Kardon, None; Bhavna J. Antony, None; Mark J. Kupersmith, None; Mona K. Garvin, Patent application (P)
  • Footnotes
    Support  NIH NEI subcontract R009040554; VA Center for the Prevention and Treatment of Visual Loss
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 2986. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Jui-Kai Wang, Randy H. Kardon, Bhavna J. Antony, Mark J. Kupersmith, Mona K. Garvin; Comparison of an Automated Method for Volumetric Quantification of Papilledema with the Frisén Scale. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2986.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose:
 

The six-stage Frisén scale is a standard, yet subjective, method to measure papilledema from fundus photography. With the goal of obtaining a more objective measure of papilledema, we developed an automated method to quantify the swollen disc volume from 3-D spectral-domain OCT scans and compared our SD-OCT volumetric measurements with the corresponding Frisén grades.

 
Methods:
 

An automated 3-D graph-theoretic multi-resolution approach was developed to segment the internal limiting membrane (ILM) and two bounding surfaces of the retinal pigment epithelial (RPE) complex in 69 3-D SD-OCT (Zeiss Cirrus) ONH-centered scans from the multiple visits of 21 subjects with papilledema acquired at The University of Iowa. The SD-OCT scans were then flattened in 3-D so the RPE complex became a flat reference plane. The volume between the ILM (orange surface in figure) and the reference plane (red surface in figure) was used as a volumetric measure of the degree of disc edema and compared to the corresponding Frisén grades resulting from independent expert (RK) evaluations of fundus photographs.

 
Results:
 

The mean (± standard deviation) resulting volumes for scales 0 to scale 4 were 10.87 ± 0.68, 11.74 ± 0.92, 13.23 ± 0.91, 14.81 ± 0.7, and 16.02 ± 0.19 mm3, respectively.

 
Conclusions:
 

Volumetric measurements of the degree of disc swelling in subjects with papilledema can be obtained from SD-OCT volumes, with the mean volume appearing to be roughly linearly related to the Frisén scale grade in this preliminary study. Using such an approach can provide a more continuous and objective means for assessing the degree of disc swelling.  

 
Keywords: optic disc • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • image processing 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×