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Lenworth N. Johnson, Chetan R. Soni, Meredith A. Johnson, Richard W. Madsen; Inhaled Corticosteroids (IHC) Do Not Appear to Produce Short-term Changes on Optical Coherence Tomography (OCT). Invest. Ophthalmol. Vis. Sci. 2011;52(14):2994.
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To assess short-term changes in optical coherence tomography (OCT) parameters with inhaled corticosteroids (IHC).
Case-control study of 185 patients with glaucoma (n=69) or glaucoma suspect (n=116), analyzing the rates of change in retinal nerve fiber layer (RNFL) thickness, and horizontal and vertical optic nerve cup-disc ratio (CDR), for IHC users (n=45 cases) and non-users (n=140 controls).
At baseline, the respective mean quadrant RNFL were 107, 68, 111, and 68 microns for cases, and 108, 69, 114, and 67 microns for controls. The respective horizontal and vertical CDRs were 0.72 and 0.64 for cases, and 0.67 and 0.62 for controls. There were no significant differences (P>0.05) in the rates of change in OCT over a 6-year period.
IHC do not appear to alter OCT parameters over a short-term period.
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