April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Macular Segmentation in Multiple Sclerosis (MS) Eyes With Optic Neuritis (ON) Episode Using Spectral Domain Optical Coherence Tomography (SD-OCT)
Chieh-Li Chen; Hiroshi Ishikawa; James Wilson; Richard A. Bilonick; Gadi Wollstein; Laura J. Balcer; Joel S. Schuman
Author Affiliations & Notes
  • Chieh-Li Chen
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • Hiroshi Ishikawa
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • James Wilson
    Departments of Neurology, Ophthalmology, and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
  • Richard A. Bilonick
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania
  • Gadi Wollstein
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • Laura J. Balcer
    Departments of Neurology, Ophthalmology, and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
  • Joel S. Schuman
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • Footnotes
    Commercial Relationships  Chieh-Li Chen, None; Hiroshi Ishikawa, Bioptigen, Inc (P); James Wilson, None; Richard A. Bilonick, None; Gadi Wollstein, Bioptigen, Inc (P), Optovue, Inc (F); Laura J. Balcer, Biogen (C), Novartis (C); Joel S. Schuman, Bioptigen, Inc (P), Carl Zeiss Meditec, Inc (P)
  • Footnotes
    Support  NIH R01-EY013178, P30-EY008098; Eye and Ear Foundation (Pittsburgh, PA); Research to Prevent Blindness.
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 2997. doi:
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      Chieh-Li Chen, Hiroshi Ishikawa, James Wilson, Richard A. Bilonick, Gadi Wollstein, Laura J. Balcer, Joel S. Schuman; Macular Segmentation in Multiple Sclerosis (MS) Eyes With Optic Neuritis (ON) Episode Using Spectral Domain Optical Coherence Tomography (SD-OCT). Invest. Ophthalmol. Vis. Sci. 2011;52(14):2997.

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Abstract

Purpose: : To investigate the retinal layer thickness in MS eyes that had a previous ON episode.

Methods: : Eleven eyes of 11 healthy volunteers and 31 eyes of 31 MS subjects were scanned with SD-OCT (Cirrus HD-OCT; Carl Zeiss Meditec, Inc., Dublin, CA; Macular Cube 200x200 and 512x128 scan pattern). All MS eyes had an episode of ON that had resolved. The thickness of the four inner-retinal layers was automatically measured at each sampling point using layer-segmentation software of our own

Results: : MS subjects were older than the healthy group (45.0±11.7 vs. 34.5±14.4 years, p=0.002, Wilcoxon test). MS eyes were statistically significantly thinner than healthy controls in all layers except for OPL and ORC (p<0.01). TR thickness showed the best AUC (0.950) and was statistically significantly higher than any other layer thickness except for GCC and IRC, (p<0.05, DeLong test).

Conclusions: : TR thickness was the most robust quantitative measurement in discriminating healthy eyes from MS eyes with a prior ON episode. This counter intuitive result may be related to variability in the effect of MS ON on specific retinal layers as well as segmentation algorithm performance.

Keywords: image processing • imaging/image analysis: clinical • neuro-ophthalmology: optic nerve 
© 2011, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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