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Chieh-Li Chen, Hiroshi Ishikawa, James Wilson, Richard A. Bilonick, Gadi Wollstein, Laura J. Balcer, Joel S. Schuman; Macular Segmentation in Multiple Sclerosis (MS) Eyes With Optic Neuritis (ON) Episode Using Spectral Domain Optical Coherence Tomography (SD-OCT). Invest. Ophthalmol. Vis. Sci. 2011;52(14):2997.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the retinal layer thickness in MS eyes that had a previous ON episode.
Eleven eyes of 11 healthy volunteers and 31 eyes of 31 MS subjects were scanned with SD-OCT (Cirrus HD-OCT; Carl Zeiss Meditec, Inc., Dublin, CA; Macular Cube 200x200 and 512x128 scan pattern). All MS eyes had an episode of ON that had resolved. The thickness of the four inner-retinal layers was automatically measured at each sampling point using layer-segmentation software of our own
MS subjects were older than the healthy group (45.0±11.7 vs. 34.5±14.4 years, p=0.002, Wilcoxon test). MS eyes were statistically significantly thinner than healthy controls in all layers except for OPL and ORC (p<0.01). TR thickness showed the best AUC (0.950) and was statistically significantly higher than any other layer thickness except for GCC and IRC, (p<0.05, DeLong test).
TR thickness was the most robust quantitative measurement in discriminating healthy eyes from MS eyes with a prior ON episode. This counter intuitive result may be related to variability in the effect of MS ON on specific retinal layers as well as segmentation algorithm performance.
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