April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Quantification Of Axonal Loss In Multiple Sclerosis And Neuromyelitis Optica Patients With Or Without Previous Episodes Of Optic Neurites Using Fourier Domain Optical Coherence Tomography
Danilo B. Fernandes; Renata P. Ramos; Rafael G F. Nogueira; Samira Apostolos-Pereira; Dagoberto Callegaro; Mario L. Monteiro
Author Affiliations & Notes
  • Danilo B. Fernandes
    Ophthalmology, University of Sao Paulo Medical School, Sao Paulo, Brazil
  • Renata P. Ramos
    Ophthalmology, University of Sao Paulo, Sao Paulo, Brazil
  • Rafael G F. Nogueira
    Ophthalmology, University of Sao Paulo, Sao Paulo, Brazil
  • Samira Apostolos-Pereira
    Neurology, University of Sao Paulo Sch of Med, Sao Paulo, Brazil
  • Dagoberto Callegaro
    Neurology, University of Sao Paulo Sch of Med, Sao Paulo, Brazil
  • Mario L. Monteiro
    Ophthalmology, University of Sao Paulo, Sao Paulo, Brazil
  • Footnotes
    Commercial Relationships  Danilo B. Fernandes, None; Renata P. Ramos, None; Rafael G F. Nogueira, None; Samira Apostolos-Pereira, None; Dagoberto Callegaro, None; Mario L. Monteiro, None
  • Footnotes
    Support  grants from Fundação de Amparo à Pesquisa do Estado de São Paulo, FAPESP (No 09/50174-0), São Paulo, Brazil and from CNPq (No 309709/2007-5), Brasília, Brazil.
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 2998. doi:
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      Danilo B. Fernandes, Renata P. Ramos, Rafael G F. Nogueira, Samira Apostolos-Pereira, Dagoberto Callegaro, Mario L. Monteiro; Quantification Of Axonal Loss In Multiple Sclerosis And Neuromyelitis Optica Patients With Or Without Previous Episodes Of Optic Neurites Using Fourier Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2998.

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Abstract

Purpose: : The quantify axonal loss using fourier-domain optical coherence tomography (3D OCT-1000®, Topcon) retinal nerve fiber layer (RNFL) and macular thickness measurements in patients with multiple sclerosis, neuromyelitis optica (NMO) and longitudinal extensive transverse myelitis ( LETM) with or without previous episodes of optic neurites(ON) and in normal controls.

Methods: : Thirty eight eyes from patients with LETM (group 1); 29 eyes from patients with NMO (group 2); 30 eyes from patients with MS and previous ON (group 3); 45 eyes from patients with MS without previous ON (group 4) and 40 age-matched normal control eyes (group 5) were studied. Subjects were submitted to standard automated perimetry and macular and RNFL measurements using 3D OCT-1000 equipment. Measurements from each group and from normal controls were compared. Receiver operating characteristic (ROC) curves were calculated for each parameter.

Results: : Most peripapillary RNFL thickness and macular thickness measurements (mean ± SD) in eyes of all 4 groups of patients were significantly smaller when compared to normal controls. While macular thickness parameters were similar in both groups, RNFL thickness measurements in eyes with ON and NMO were significantly smaller than eyes with ON and MS. When eyes of patients with LETM (group 1) and eyes with MS without history of ON (group 4) were compared, no significant difference was found in measurents.

Conclusions: : Fourier-domain OCT RNFL and macular thickness measurements can detect axonal loss in patients with NMO, MS both, with and without ON, and also in patients with LETM. These findings indicate that similar to MS subclinical attacks of optic neuritis may also occur in LETM patients. While full thickness macular measurments showed similar findings in both groups, OCT RNFL thickness measurements confirm previous studies suggesting a more severe axonal damage in eyes with ON from NMO when compared with those with ON from MS.

Clinical Trial: : http://www.clinicaltrials.gov NCT01024985

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • nerve fiber layer • neuro-ophthalmology: optic nerve 
© 2011, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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