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Gabor M. Somfai, Erika Tátrai, Magdolna Simo, Anna Iljicsov, János Németh, Delia DeBuc; In Vivo Evaluation Of Retinal Neurodegeneration In Patients With Multiple Sclerosis. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2999.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate macular morphology in patients with multiple sclerosis (MS).
Optical coherence tomography (OCT) examination was performed in twenty-three patients with MS and three patients with previous unilateral ON as a clinically isolated syndrome. The raw macular OCT data were processed using OCTRIMA software. Weighted mean thickness (WMT) of the total retina and 5 intraretinal layers were obtained. The eyes of MS patients were divided into 2 groups; the first group was composed of 26 ON-affected eyes (AE group), while the remaining 23 eyes had no history of ON (non-affected eyes - NE group). Thickness values were compared using ANOVA with Newman-Keuls post-hoc analysis. ROC curves were constructed to determine which parameter can discriminate best between ON-affected and healthy eyes.
The WMT of the macula, RNFL and ganglion cell layer and inner plexiform layer complex (GCL+IPL) was significantly decreased in the NE group compared to controls (p=0.002, 0.001 and <0.001, respectively) and in the AE group compared to NE group (p<0.001 for each comparison). The largest AUC (1.0) was obtained for the WMT of the ganglion cell complex (comprising the RNFL and GCL+IPL).
Thinning of the ganglion cell complex in the inner retina is present in both the ON-affected and non-affected eyes of MS patients. Macular OCT image segmentation might provide a better insight into macular and general pathology of neurodegeneration and could therefore play an important role in the diagnosis and follow-up of patients with MS.
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