Purchase this article with an account.
Linda M. Zangwill, Stefano Miglior, Esther M. Hoffmann, Sonia Jain, Norbert Pfeiffer, Feng He, Eliana Rulli, Irene C. Floriani, Thierry Zeyen, Mae O. Gordon; Confocal Scanning Laser Ophthalmoscopy (CSLO) To Predict The Onset Of Primary Open Angle Glaucoma (POAG): Pooled Analysis Of The CSLO Ancillary Study To The Ocular Hypertension Treatment Study (OHTS) And The European Glaucoma Prevention Study (EGPS). Invest. Ophthalmol. Vis. Sci. 2011;52(14):3060.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To pool CSLO data from the OHTS and the EGPS to improve the prediction of the development of POAG in ocular hypertensive subjects.
222 subjects with good quality Heidelberg Retina Tomograph (HRT) images from the observation group of the CSLO Ancillary Study to the OHTS and 229 subjects from the EGPS placebo group were included. Based on stringent statistical testing to determine if pooling the studies was appropriate, the data from the two studies was judged to be appropriate for pooling. The ability of global and sectoral neuroretinal rim, optic cup and retinal nerve fiber layer parameters to predict the development of POAG were evaluated in multivariable models adjusting for age, IOP, central corneal thickness and HRT disc area.
27 OHTS participants and 31 EGPS participants developed POAG; median time to POAG was 3.9 years. Median follow-up for participants who did not develop POAG was 5.0 years. In multivariable models larger baseline rim area (HR: 0.68 per 0.2 mm2), rim volume (HR: 0.73 per 0.1 mm3), and RNFL thickness (HR: 0.57 per .1mm) significantly decreased the probability of developing POAG. Larger baseline cup area (HR: 1.8 per 0.3mm2), cup volume (1.2 per 0.1 mm3) and cup disc area ratio (HR: 1.5 per .1mm) and baseline outside normal limits results for Moorfields Regression Analysis (HR: 2.3) and Glaucoma Probability Score (HR: 2.0) significantly increased the probability of developing POAG. The predictive ability of baseline HRT rim and cup area were similar to the predictive ability of models that include stereophoto based cup disc ratio.
The OHTS CSLO predictive model was validated in the EGPS placebo group. These results strengthen the evidence that CSLO measurements can be used in models to predict the onset of POAG in patients with ocular hypertension.
Clinical Trial: :
This PDF is available to Subscribers Only