April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Confocal Scanning Laser Ophthalmoscopy (CSLO) To Predict The Onset Of Primary Open Angle Glaucoma (POAG): Pooled Analysis Of The CSLO Ancillary Study To The Ocular Hypertension Treatment Study (OHTS) And The European Glaucoma Prevention Study (EGPS)
Linda M. Zangwill; Stefano Miglior; Esther M. Hoffmann; Sonia Jain; Norbert Pfeiffer; Feng He; Eliana Rulli; Irene C. Floriani; Thierry Zeyen; Mae O. Gordon
Author Affiliations & Notes
  • Linda M. Zangwill
    Ophthalmology,
    Univ of California-San Diego, La Jolla, California
  • Stefano Miglior
    Ophthalmology, Policlinico di Monza, Universita Milano Bicocca, Monza (MI), Italy
  • Esther M. Hoffmann
    Ophthalmology, University of Mainz, Mainz, Germany
  • Sonia Jain
    Family and Preventive Medicine,
    Univ of California-San Diego, La Jolla, California
  • Norbert Pfeiffer
    Ophthalmology, University of Mainz, Mainz, Germany
  • Feng He
    Family and Preventive Medicine,
    Univ of California-San Diego, La Jolla, California
  • Eliana Rulli
    Instituto Mario Negri, Milan, Italy
  • Irene C. Floriani
    Mario Negri, Istituto di Ricerche Farmacologiche, Milan, Italy
  • Thierry Zeyen
    Ophthalmology, University of Leuven, Leuven, Belgium
  • Mae O. Gordon
    Ophthal & Vis Sciences, Washington Univ Sch of Med, St Louis, Missouri
  • Footnotes
    Commercial Relationships  Linda M. Zangwill, Carl Zeiss Meditec Inc. (F), Heidelberg Engineering (R), Heidelberg Engineering GmbH (F), Optovue Inc. (F), Topcon Medical Systems Inc. (F); Stefano Miglior, None; Esther M. Hoffmann, Carl Zeiss Meditec (F), Heidelberg Engineering (F); Sonia Jain, None; Norbert Pfeiffer, None; Feng He, None; Eliana Rulli, None; Irene C. Floriani, None; Thierry Zeyen, None; Mae O. Gordon, None
  • Footnotes
    Support  NIH grants: EY11158, EY09117, EY09341, EY09307. Merck & Co, European Commission, National Center on Minority Health and Health Disparities, Unrestricted grants from Research to Prevent Blindness
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3060. doi:
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      Confocal Scanning Laser Ophthalmoscopy (CSLO) To Predict The Onset Of Primary Open Angle Glaucoma (POAG): Pooled Analysis Of The CSLO Ancillary Study To The Ocular Hypertension Treatment Study (OHTS) And The European Glaucoma Prevention Study (EGPS)
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      Linda M. Zangwill, Stefano Miglior, Esther M. Hoffmann, Sonia Jain, Norbert Pfeiffer, Feng He, Eliana Rulli, Irene C. Floriani, Thierry Zeyen, Mae O. Gordon; Confocal Scanning Laser Ophthalmoscopy (CSLO) To Predict The Onset Of Primary Open Angle Glaucoma (POAG): Pooled Analysis Of The CSLO Ancillary Study To The Ocular Hypertension Treatment Study (OHTS) And The European Glaucoma Prevention Study (EGPS). Invest. Ophthalmol. Vis. Sci. 2011;52(14):3060.

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Abstract

Purpose: : To pool CSLO data from the OHTS and the EGPS to improve the prediction of the development of POAG in ocular hypertensive subjects.

Methods: : 222 subjects with good quality Heidelberg Retina Tomograph (HRT) images from the observation group of the CSLO Ancillary Study to the OHTS and 229 subjects from the EGPS placebo group were included. Based on stringent statistical testing to determine if pooling the studies was appropriate, the data from the two studies was judged to be appropriate for pooling. The ability of global and sectoral neuroretinal rim, optic cup and retinal nerve fiber layer parameters to predict the development of POAG were evaluated in multivariable models adjusting for age, IOP, central corneal thickness and HRT disc area.

Results: : 27 OHTS participants and 31 EGPS participants developed POAG; median time to POAG was 3.9 years. Median follow-up for participants who did not develop POAG was 5.0 years. In multivariable models larger baseline rim area (HR: 0.68 per 0.2 mm2), rim volume (HR: 0.73 per 0.1 mm3), and RNFL thickness (HR: 0.57 per .1mm) significantly decreased the probability of developing POAG. Larger baseline cup area (HR: 1.8 per 0.3mm2), cup volume (1.2 per 0.1 mm3) and cup disc area ratio (HR: 1.5 per .1mm) and baseline outside normal limits results for Moorfields Regression Analysis (HR: 2.3) and Glaucoma Probability Score (HR: 2.0) significantly increased the probability of developing POAG. The predictive ability of baseline HRT rim and cup area were similar to the predictive ability of models that include stereophoto based cup disc ratio.

Conclusions: : The OHTS CSLO predictive model was validated in the EGPS placebo group. These results strengthen the evidence that CSLO measurements can be used in models to predict the onset of POAG in patients with ocular hypertension.

Clinical Trial: : http://www.clinicaltrials.gov NCT00000125

Keywords: imaging/image analysis: clinical 
© 2011, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2015 Association for Research in Vision and Ophthalmology.
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