April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Reticular Autofluorescence and Its Associated Features in the Age Related Eye Disease Study 2(AREDS2)
Author Affiliations & Notes
  • Amitha Domalpally
    Ophthalmology, Fundus Photograph Reading Center, Madison, Wisconsin
  • Christina Kruse
    Ophthalmology, Fundus Photograph Reading Center, Madison, Wisconsin
  • Barbara Blodi
    Ophthalmology, Fundus Photograph Reading Center, Madison, Wisconsin
  • Larry Hubbard
    Ophthalmology, Fundus Photograph Reading Center, Madison, Wisconsin
  • Emily Y. Chew
    Epidemiology & Clinical Applications, National Eye Inst/NIH, Bethesda, Maryland
  • Ronald Danis
    Ophthalmology, Fundus Photograph Reading Center, Madison, Wisconsin
  • AREDS2 Research Group
    Ophthalmology, Fundus Photograph Reading Center, Madison, Wisconsin
  • Footnotes
    Commercial Relationships  Amitha Domalpally, None; Christina Kruse, None; Barbara Blodi, None; Larry Hubbard, None; Emily Y. Chew, None; Ronald Danis, None
  • Footnotes
    Support  Research to Prevent Blindness
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3070. doi:
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      Amitha Domalpally, Christina Kruse, Barbara Blodi, Larry Hubbard, Emily Y. Chew, Ronald Danis, AREDS2 Research Group; Reticular Autofluorescence and Its Associated Features in the Age Related Eye Disease Study 2(AREDS2). Invest. Ophthalmol. Vis. Sci. 2011;52(14):3070.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

Reticular autofluorescence( AF) has been associated with reticularpseudo-drusen and progression to advanced age-related maculardegeneration (AMD). The purpose of this study is to evaluatethe association between reticular AF and reticular pseudo- drusenfrom color photographs in AREDS2 participants.

 
Methods:
 

Color fundus photographs (3 field stereo) and correspondingAF images (HRA2 and Spectralis, Heidelberg Eng.), were evaluatedat annual visits in the AREDS2 AF ancillary study. Eyes withreticular AF detected for the first time at any visit were correlatedwith reticular pseudo-drusen on color photographs( figure 1).If reticular pseudo-drusen were absent, the image was reviewedin the blue channel of the RGB color before confirming theirabsence( figure 2). Eyes with neovascular AMD and/or poor imagequality were excluded.

 
Results:
 

Among 1892 eyes (948 subjects) with color and AF available,reticular AF were seen in 214 (11.3%) eyes (153 subjects). Ofthese, 106 (49.5%) eyes showed reticular pseudo-drusen on correspondingcolor photographs. The remaining 108 color photographs werere-evaluated in the blue channel and reticular pseudo-drusenwere seen in 45 (41.6%) eyes; 34(31.5%) eyes were ungradablein the blue channel.

 
Conclusions:
 

Reticular AF corresponds to reticular pseudo-drusen in the majorityof eyes. Both auto fluorescence and blue channel evaluationof color photographs and are sensitive modalities for imagingreticular pseudo-drusen.  

 

 
Clinical Trial:
 

http://www.clinicaltrials.gov NCT00345176

 
Keywords: age-related macular degeneration • imaging/image analysis: clinical • drusen 
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