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Takako Tachikawa, Ritsuko Ueno, Daisuke Yuzurihara, Tetsuko Mita, Hiroki Tanaka, Osamu Katsumi, Toru Noda, Kazuhiko Ohnuma; Wavefront Analysis Of High-order Aberrations And Refractive Errors In Premature Children After Diode Laser Treatment For Retinopathy Of Prematurity. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3131.
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© ARVO (1962-2015); The Authors (2016-present)
To determine high-order aberrations and local refractive changes in premature children after diode laser for retinopathy of prematurity (ROP).
We performed an analytic retrospective study of patients who underwent aberrometry. One hundred thirty eyes of 67 subjects (mean age, 6.73 ± 3.55 years) were examined at the Tokyo Metropolitan Ohtsuka Hospital in 2010. We analyzed the cycloplegic refractions (spherical equivalent [SE] and astigmatism) and high-order aberrations of the cornea and internal optics. All data were obtained by wavefront analysis (KR-9000PW Topcon, Japan) with a 6.0-mm optical zone. Patients were divided into three group based on ROP treatment: group 1, circumferential diode laser photocoagulation (28 eyes; gestational age, 25.1±1.3 weeks); group 2, hemispherical laser photocoagulation (30 eyes; gestational age, 26.7±1.7 weeks); group 3, no photocoagulation (42 eyes, gestational age, 27.0±1.8 weeks), and controls (30 eyes, preterm infants).
The average SE was -4.99±4.42 diopters (D) in group1, -1.18±2.88 D in group 2, +1.09±1.99 D in group 3, and +2.15±2.15 D in controls. The average astigmatism was -2.59±1.25 D in group 1, -1.30±1.04 D in group 2, -1.49±1.31 D in group 3, and -1.63±1.15 D in controls. The mean internal optical spherical aberration was 0.199 µm in group 1, 0.013 µm in group 2, -0.070 µm in group 3, and -0.137 µm in controls. The internal optical coma was 0.426 µm in group 1, 0.425µm in group 2, 0.426 µm in group 3, and 0.395 µm in controls. Group 1 had significantly higher internal optical spherical aberration than the others (P<0.01), but there was no significant difference in internal optical coma among the four groups (P>0.01). However, group 1 had lower corneal spherical aberration (0.066 µm) than the others (group 2, 0.160 µm; group 3, 0.200 µm; and controls, 0.178 µm). There was a positive correlation between the root mean square of the internal optical spherical aberration and the SE (r=-0.691, P=0.0003) and astigmatism (r=-0.527, P=0.0062) in group 1.
Our results suggested that photocoagulation for premature infants might affect the internal optical spherical aberration.
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