April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
ERG and Visual Acuity In Preterm Babies
Domenico Lepore; Fernando Molle; Monica M. Pagliara; Lorenzo Orazi; Eliana Costanzo; Carmine Angora; Antonio Baldascino; Salvatore Luceri; Ferdinando Lafranceschina; Benedetto Falsini
Author Affiliations & Notes
  • Domenico Lepore
    Department of Ophthalmology, Catholic University, Rome, Italy
  • Fernando Molle
    Department of Ophthalmology, Catholic University, Rome, Italy
  • Monica M. Pagliara
    Department of Ophthalmology, Catholic University, Rome, Italy
  • Lorenzo Orazi
    Department of Ophthalmology, Catholic University, Rome, Italy
  • Eliana Costanzo
    Department of Ophthalmology, Catholic University, Rome, Italy
  • Carmine Angora
    Department of Ophthalmology, Catholic University, Rome, Italy
  • Antonio Baldascino
    Department of Ophthalmology, Catholic University, Rome, Italy
  • Salvatore Luceri
    Department of Ophthalmology, Catholic University, Rome, Italy
  • Ferdinando Lafranceschina
    Department of Ophthalmology, Catholic University, Rome, Italy
  • Benedetto Falsini
    Department of Ophthalmology, Catholic University, Rome, Italy
  • Footnotes
    Commercial Relationships  Domenico Lepore, None; Fernando Molle, None; Monica M. Pagliara, None; Lorenzo Orazi, None; Eliana Costanzo, None; Carmine Angora, None; Antonio Baldascino, None; Salvatore Luceri, None; Ferdinando Lafranceschina, None; Benedetto Falsini, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3135. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      ERG and Visual Acuity In Preterm Babies
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      Domenico Lepore, Fernando Molle, Monica M. Pagliara, Lorenzo Orazi, Eliana Costanzo, Carmine Angora, Antonio Baldascino, Salvatore Luceri, Ferdinando Lafranceschina, Benedetto Falsini; ERG and Visual Acuity In Preterm Babies. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3135.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Purpose: : to verify if premature birth, with or without ROP could modify central retinal developmente and therefore affect central retinal function.

Methods: : 13 inborn preterms with an history of bilateral symmetric stage 2 or 3 ROP in zone 2 (mild ROP) were evaluated between 4 and 7 years of age.The mean gestational age (GA) was 28 weeks and the mean birth weight (BW) was 869gr. We also studied 11 inborn premature babies without ROP; their mean GA was 30 weeks and 1the mean BW was 1313g. ERG allows to evaluate panretinal damage obtaining a layer by layer analysis. To study the internal retina we used pattern ERG (p-ERG). To study the external retina we used focal ERG 41Hz (f-ERG). Normative values of a non premature babies population from previous studies were compared to our data.

Results: : in non prematures babies f-ERG amplitude is 2.45µV and p-ERG amplitude is 1.85µV. In our study the mean visual acuity (VA) of babies with ROP was 0,81, while the VA of the prematures without ROP was 0,99 (p=0.05). In the prematures babies the mean f-ERG amplitude was 1.11µV and the mean p-ERG amplitude was 1.25µV. In the mild ROP group the mean f-ERG amplitude was 1.16µV and that of p-ERG was 1.11µV. A significant f-ERG amplitude reduction is present in both group (-50.97% DS 25.9) if compared to the normative values from non prematures babies population: this difference does not correlates with ROP, GA, BW, or VA. The pERG amplitude loss is linearly correlated to GA but not with ROP, BW and VA. The f-ERG loss does not correlate with p-ERG loss.

Conclusions: : Using fERG we have been able to demonstrate a damage of external retinal in preterm with or without an history of mild ROP. In previous studies we were able to show persistent choroideal alterations in preterm babies: we can therefore speculates that choroideal hypoxia could damages photoreceptor in this population. Further studies are needed to understand the mechanism of internal retina involvement.

Keywords: retinopathy of prematurity • electroretinography: clinical 
© 2011, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept