April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Retinopathy Of Prematurity In Small-for-gestational-age Premature Infants
Author Affiliations & Notes
  • Julio A. Urrets-Zavalia
    Ophthalmology, University Clinic Reina Fabiola, Universidad Catolica de Cordoba, Cordoba, Argentina
  • Erna G. Knoll
    Ophthalmology, University Clinic Reina Fabiola, Universidad Catolica de Cordoba, Cordoba, Argentina
  • Maria E. Fornies-Paz
    Ophthalmology, University Clinic Reina Fabiola, Universidad Catolica de Cordoba, Cordoba, Argentina
  • Nicolas Crim
    Ophthalmology, University Clinic Reina Fabiola, Universidad Catolica de Cordoba, Cordoba, Argentina
  • Paula B. Lopez-Giordano
    Ophthalmology, University Clinic Reina Fabiola, Universidad Catolica de Cordoba, Cordoba, Argentina
  • Rodolfo Monti
    Ophthalmology, University Clinic Reina Fabiola, Universidad Catolica de Cordoba, Cordoba, Argentina
  • Elizabeth Collino
    Neonatology, Hospital Materno-Neonatal Ramon Carrillo, Cordoba, Argentina
  • Horacio M. Serra
    CIBICI-CONICET, Faculty of Chemical Sciences, Universidad Nacional de Cordoba, Cordoba, Argentina
  • Footnotes
    Commercial Relationships  Julio A. Urrets-Zavalia, None; Erna G. Knoll, None; Maria E. Fornies-Paz, None; Nicolas Crim, None; Paula B. Lopez-Giordano, None; Rodolfo Monti, None; Elizabeth Collino, None; Horacio M. Serra, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3150. doi:
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      Julio A. Urrets-Zavalia, Erna G. Knoll, Maria E. Fornies-Paz, Nicolas Crim, Paula B. Lopez-Giordano, Rodolfo Monti, Elizabeth Collino, Horacio M. Serra; Retinopathy Of Prematurity In Small-for-gestational-age Premature Infants. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3150.

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Abstract

Purpose: : To evaluate the possible association between retinopathy of prematurity (ROP) and percentiles of birth: according-to-gestational-age (AGA), small-for-gestational-age (SGA), or large-for-gestational-age (LGA) premature infants (PI).

Methods: : 117 PI were evaluated prospectively in the Neonatology department of a 3rd level public hospital in Cordoba, Argentina, that were born at or with a referral of ≤24 h to our unit from May 2009 through November 2010, in order to evaluate ROP prevalence and severity. In each control, body weight and weight gain were recorded, and both eyes fully dilated and examined with binocular indirect ophthalmoscopy by experienced ophthalmologists in ROP screening. First exam was performed between the 2nd and the 4th week of life.

Results: : Infants were grouped according to birth weight (BW): ≤1000g (10 infants-8.5%), 1000-1500g (26-22.2%), 1500-2000g (32-27.3%), 2000-2500g (34-29%), ≥2500g (15-12.8%); according to gestational age (GA): ≤29 weeks (7 infants-5.9%), 29-32 weeks GA (33-28.2%) and 33-36 weeks (77-65.8%), and according to their percentiles they were classified in SGA (45patients-38.5%), AGA (69-59%), and LGA (3-2.5%). Mean weight gain (WG) was: SGA 19.8±6.2g/day (r=20.28 to 23.60); AGA 15.84 ± 9.56g/day (r= -10.65 to 41.66) and LGA 3.46 ± 1.09g/day (r=2.50 to 4.65). All types ROP were diagnosed in 11 (9.4%) patients; 10 infants (90.9%) were SGA, 1 (9.1%) AGA and none was LGA. In 5 infants (45.5%) had type 1 ROP; 4 of those infants (36.5%) were treated and 1 showed spontaneous involution. The principal related causes for SGA prematurity were uncontrolled gestation and maternal malnutrition.

Conclusions: : The prevalence of ROP was extremely high in SGA premature infants compared with PI that were in accordance with GA. Severe ROP was also higher in SGA PI compared with PI that were in accordance with GA. SGA prematurity should be considered an important risk factor for ROP blindness, and those infants should be monitored carefully.

Keywords: retinopathy of prematurity 
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