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Antonio Baldascino, Velia Purcaro, Domenico Lepore, Fernando Molle, Patrizia Papacci, Carmen Giannantonio, Lorenzo Orazi, Carmine Angora, Mikael Ghennet Tesfagabir, Costantino Romagnoli; Evolution of Fluorangiographic Findings in ROP. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3151.
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to define progression of fluorescein angiographic findings in preterms with ROP in order to optimize timing of treatment.
from August ‘09 20 inborn preterm with gestational age (GA) <29 wks and/or birth weight (BW) <1000gr were screened for ROP with RETCAM digital fluorescein angiography (Massie Lab., Pleasanton, CA) every two weeks from 31 wks of GA until the discharge from the neonatal intensive care unit at the Catholic University Hospital in Rome. The mean BW was 685gr (range 440-1050gr) and the mean GA was 26,7wks (range 24,3-29,3wks). ROP was diagnosed in all babies; 12 eyes (6 babies) type1 ROP were treated at pre-threshold level; 8 eyes (4 babies) progressing from type 2 to type 1 were also treated; 4 eyes (2 babies) classified as type 2 and 16 eyes ( 8 babies ) with ROP stage 2 zone II without plus were observed until the regression.
FA showed a variable timing of arterious, venous and choroidal phases. All cases showed a certain degree of fluorangiographic abnormalities, some concordant with ophthalmoscopic aspect of ROP some not. Most common feature, according to our previous studies, were the findings at the junction between vascular and avascular retina: abnormal vessels branching, naked shunts, capillary free areas of hypoperfusion and teleangectasia. Cotton wools like and pop corn were found only in severe cases, macular abnormalities in all ROP in zone I. Dye leakage is the most significant sign of progression to type 1 ROP.
FA is an important tool in the comprehension of the ROP evolution toward regression or progression to type 1.
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