April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Erythropoietin Receptor Positive Circulating Progenitor Cells and Endothelial Progenitor Cells in Patients with Different Stages of Diabetic Retinopathy
Weiye Li; Xia Lei; Bo Ma; Yu Zhang; Yan Yan; Guo-Tong Xu
Author Affiliations & Notes
  • Weiye Li
    Ophthalmology, Drexel University College of Medicine, Philadelphia, Pennsylvania
    Tongji Eye Institute and Department of Regenerative Medicine, Tongji University School of Medicine, Shanghai, China
  • Xia Lei
    Tongji Eye Institute and Department of Regenerative Medicine, Tongji University School of Medicine, Shanghai, China
    Institute of Health Sciences (IHS), SIBS, CAS & SJTUSM, Shanghai, China
  • Bo Ma
    Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China
  • Yu Zhang
    Department of Ophthalmology, Huashan Hospital Affiliated to Fudan University, S, China
  • Yan Yan
    Department of Ophthalmology, Ruijin Hospital Affiliated to SJTUSM, Shanghai, China
  • Guo-Tong Xu
    Tongji Eye Institute and Department of Regenerative Medicine, Tongji University School of Medicine, Shanghai, China
    Institute of Health Sciences (IHS), SIBS, CAS & SJTUSM, Shanghai, China
  • Footnotes
    Commercial Relationships  Weiye Li, None; Xia Lei, None; Bo Ma, None; Yu Zhang, None; Yan Yan, None; Guo-Tong Xu, None
  • Footnotes
    Support  Supported by Sciences and Technology Commission of Shanghai Municipality (#08410701200) and Unrestricted Research Fund from the Clear Vision Foundation, Philadelphia USA.
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3170. doi:
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      Weiye Li, Xia Lei, Bo Ma, Yu Zhang, Yan Yan, Guo-Tong Xu; Erythropoietin Receptor Positive Circulating Progenitor Cells and Endothelial Progenitor Cells in Patients with Different Stages of Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3170.

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Abstract

Purpose: : To investigate the involvement of erythropoietin (EPO)/erythropoietin receptor (EPOR) system in neovascularization and vascular regeneration in diabetic retinopathy (DR).

Methods: : EPOR positive circulating progenitor cells (CPCs: CD34+) and endothelial progenitor cells (EPCs: CD34+KDR+) were assessed in type 2 diabetic patients with different stages of DR by flow cytometry. This cohort consisted of seven age- and sex-matched patients (control), seven with non-proliferative DR (NPDR), eight with active proliferative DR (PDR), and seven with active PDR as well as diabetic nephropathy (PDR-DN).

Results: : Both the number of EPOR+ CPCs or EPOR+ EPCs and the proportion of these cells in CPCs or EPCs were reduced remarkably in NPDR, whereas, they were rebounded in active PDR and PDR-DN.

Conclusions: : These findings suggest that exogenous EPO, mediated via the EPO/EPOR system of EPCs, may alleviate the impaired vascular regeneration in NPDR, whereas it might aggravate retinal neovascularization due to a rebound of EPOR+ EPCs associated with ischemia in PDR.

Keywords: diabetic retinopathy • retinal neovascularization 
© 2011, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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