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Weiye Li, Xia Lei, Bo Ma, Yu Zhang, Yan Yan, Guo-Tong Xu; Erythropoietin Receptor Positive Circulating Progenitor Cells and Endothelial Progenitor Cells in Patients with Different Stages of Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3170.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the involvement of erythropoietin (EPO)/erythropoietin receptor (EPOR) system in neovascularization and vascular regeneration in diabetic retinopathy (DR).
EPOR positive circulating progenitor cells (CPCs: CD34+) and endothelial progenitor cells (EPCs: CD34+KDR+) were assessed in type 2 diabetic patients with different stages of DR by flow cytometry. This cohort consisted of seven age- and sex-matched patients (control), seven with non-proliferative DR (NPDR), eight with active proliferative DR (PDR), and seven with active PDR as well as diabetic nephropathy (PDR-DN).
Both the number of EPOR+ CPCs or EPOR+ EPCs and the proportion of these cells in CPCs or EPCs were reduced remarkably in NPDR, whereas, they were rebounded in active PDR and PDR-DN.
These findings suggest that exogenous EPO, mediated via the EPO/EPOR system of EPCs, may alleviate the impaired vascular regeneration in NPDR, whereas it might aggravate retinal neovascularization due to a rebound of EPOR+ EPCs associated with ischemia in PDR.
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