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Nora W. Muakkassa, Aditya Athanikar, Varun Verma, Jesse Cohen, Ben Cohen, Jeffrey Paccione, Kenneth Wald; IVFA Findings in the Fellow Eye Upon Diagnosis of Central Serous Retinopathy in Chinese Patients: A Larger Cohort Study. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3613.
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© ARVO (1962-2015); The Authors (2016-present)
Central serous retinopathy (CSR) is characterized by an exudative neurosensory retinal detachment, resulting in decreased visual acuity and/or metamorphopsia. The etiology and risk factors are not fully established. A genetic/racial component has not been reported. The authors noted a greater degree of bilateral involvement in Chinese patients and therefore hypothesized that Chinese patients may show a higher incidence of IVFA findings in the fellow eye than non-Chinese patients. The authors had presented a similar study with a smaller cohort as part of ARVO 2010. We now present the study with a larger cohort of 166 cases.
This study reports IVFA findings in the clinically unaffected eye (fellow eye) at the time of diagnosis of acute CSR in the symptomatic eye. It was conducted as a retrospective chart review of 166 consecutive cases from 2004-2010 referred to a vitreoretinal group in New York City with a large volume of immigrant patients. The diagnosis of CSR was based on clinical examination, OCT and often IVFA. Exclusion criteria included diagnoses of any other prior retinal disease. The IVFA findings in the fellow eye were categorized into four groups; no defects, irregular transmission defects (representing resolved fluid accumulation), sharp defects (representing pigment epithelial detachment) and progressive hyperfluorescence (leakage).
Out of 166 cases, 32 were Chinese (26 males, 6 females) and 134 were non-Chinese (103 males, 31 females). The average age of Chinese patients was 45.8 years and of non-Chinese was 46.5 years. Chinese patients were more likely to demonstrate leakage than non-Chinese patients (p=.031; Fisher’s Exact Test [FET]; odds ratio [OR] 3.6; 95% confidence interval [CI]=1.2-11.4). There was no difference in the occurrence of defects between the groups, however among those with defects, Chinese patients were more likely to have leakage vs other defects than their non-Chinese counterparts (p=.01;FET;OR=8.1;CI=1.7-38.1).
Chinese patients showed a significantly increased prevalence of active disease in the fellow eye on IVFA than non-Chinese patients. Among those with abnormal findings in the fellow eye, Chinese patients were more likely have leakage than other defects. This may suggest a racial/genetic component to developing CSR.
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