April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
A New Reflectance Method to Determine the Macular Pigment Density: Investigation of Reproducibility and Variability
Author Affiliations & Notes
  • Elke Machalett
    Carl Zeiss Meditec AG, Jena, Germany
  • Annika Rudolf
    Carl Zeiss Meditec AG, Jena, Germany
  • Martin Noelke
    Carl Zeiss Meditec AG, Jena, Germany
  • Kathleen Kunert
    Helios Klinikum, Erfurt, Germany
  • Footnotes
    Commercial Relationships  Elke Machalett, Carl Zeiss Meditec AG (E); Annika Rudolf, Carl Zeiss Meditec AG (E); Martin Noelke, Carl Zeiss Meditec AG (E); Kathleen Kunert, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3620. doi:
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      Elke Machalett, Annika Rudolf, Martin Noelke, Kathleen Kunert; A New Reflectance Method to Determine the Macular Pigment Density: Investigation of Reproducibility and Variability. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3620.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To evaluate a new instrument for determination of macular pigment density with regard to its reproducibility and examiner and system variability.

Methods: : The study was conducted on patients with healthy eyes (27 ± 5 years; 43% male, 57% female) by three examiners on three VISUCAM 200 systems.The captured blue images were used to calculate four parameters of the macular pigment density: area, volume, maxOD and meanOD.

Results: : Good reproducibility was observed both between the systems and between the examiners. The variation coefficients totaled between 1.71 - 3.83%.For the area, the mean standard deviation lay at 5% for both the three examiners and for the three systems, at 6% for volume, at 3% for meanOD, and at 4% (examiners) and 3% (systems) for maxOD.The results on examiner and system variability show no statistically significant differences (p > 0.05) for area, volume and meanOD.

Conclusions: : The evaluated instrument offers a reproducible method for determining macular pigment density.The results are independent of examiner and system.

Keywords: macular pigment • imaging/image analysis: clinical • clinical (human) or epidemiologic studies: systems/equipment/techniques 

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