Abstract
Purpose: :
To determine macular pigment optical density (MPOD) using the heterochromatic flicker photometry in normal Asian Indian eyes and to investigate its correlation with central foveal thickness.
Methods: :
We determined MPOD using the Tinsley macular pigment densitometer (Tinsley Ophthalmic, Surrey, UK) which measures macular pigment absorption density with a stimulus of 1° test field. Foveal thickness was obtained using 20 × 15 degree raster scans consisting of 37 high-resolution line scans in a spectral domain optical coherence tomography (Spectralis, Heidelberg Engineering, Germany); the mean foveal thickness was calculated corresponding to the central 1 mm of the Early Treatment Diabetic Retinopathy Study (ETDRS) area.
Results: :
89 eyes (44 subjects) were analyzed (23 males and 21 females); mean age was 32.5 ±12.3 (range, 18-70) years. The mean MPOD was 0.415 (95% C.I, 0.387-0.444) and the mean foveal thickness was 227.2 µ (95% C.I, 221.9-232.5). MPOD correlated poorly with foveal thickness (r=0.07, p=0.5). Males showed higher MPOD values compared to females (r=-0.30, 95% C.I, -0.55-0.01, p<0.05); however, there was no inter-eye asymmetry (r=0.61, 95% C.I, 0.38-0.75, p<0.0001).
Conclusions: :
MPOD does not appear to correlate with central foveal thickness in normal Asian Indian eyes.
Keywords: macular pigment • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • macula/fovea