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Koushik R. Sargod, Rohit Shetty, Bhujang K. Shetty, Sriharsha Nagaraj, Padmamalini Mahendradas, Kavitha Avadhani, Rajesh Sasikumar; Spatial Profile of Macular Pigment Density and Correlation with Central Foveal Thickness in Normal Asian Indian Eyes. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3635.
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© ARVO (1962-2015); The Authors (2016-present)
To determine macular pigment optical density (MPOD) using the heterochromatic flicker photometry in normal Asian Indian eyes and to investigate its correlation with central foveal thickness.
We determined MPOD using the Tinsley macular pigment densitometer (Tinsley Ophthalmic, Surrey, UK) which measures macular pigment absorption density with a stimulus of 1° test field. Foveal thickness was obtained using 20 × 15 degree raster scans consisting of 37 high-resolution line scans in a spectral domain optical coherence tomography (Spectralis, Heidelberg Engineering, Germany); the mean foveal thickness was calculated corresponding to the central 1 mm of the Early Treatment Diabetic Retinopathy Study (ETDRS) area.
89 eyes (44 subjects) were analyzed (23 males and 21 females); mean age was 32.5 ±12.3 (range, 18-70) years. The mean MPOD was 0.415 (95% C.I, 0.387-0.444) and the mean foveal thickness was 227.2 µ (95% C.I, 221.9-232.5). MPOD correlated poorly with foveal thickness (r=0.07, p=0.5). Males showed higher MPOD values compared to females (r=-0.30, 95% C.I, -0.55-0.01, p<0.05); however, there was no inter-eye asymmetry (r=0.61, 95% C.I, 0.38-0.75, p<0.0001).
MPOD does not appear to correlate with central foveal thickness in normal Asian Indian eyes.
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