April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Retinal Layer Thickness Analysis of Non-proliferative Diabetic Retinopathy by Spectral Domain Optical Coherence Tomography
Author Affiliations & Notes
  • Jennifer I. Lim
    Ophthal-Eye & Ear Infirm, Univ of Illinois at Chicago, Chicago, Illinois
  • Ruth Zelkha
    Ophthal-Eye & Ear Infirm, Univ of Illinois at Chicago, Chicago, Illinois
  • Mahnaz Shahidi
    Ophthal-Eye & Ear Infirm, Univ of Illinois at Chicago, Chicago, Illinois
  • Footnotes
    Commercial Relationships  Jennifer I. Lim, None; Ruth Zelkha, None; Mahnaz Shahidi, None
  • Footnotes
    Support  Cless Retina Research Fund (JIL), NIH grant EY014275 (MS) and Dept of VA (MS), Research to Prevent Blindness and NIH Core Grant EY01792
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3656. doi:
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    • Get Citation

      Jennifer I. Lim, Ruth Zelkha, Mahnaz Shahidi; Retinal Layer Thickness Analysis of Non-proliferative Diabetic Retinopathy by Spectral Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3656.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To compare thickness of inner and outer retinal layers in nine ETDRS macular subfield areas from SDOCT images amongst three groups of eyes: non-proliferative diabetic retinopathy (NPDR) with clinically significant diabetic macular edema (CSDME), NPDR without CSDME and normals.

Methods: : Patients with NPDR and normal subjects underwent SDOCT imaging. The internal limiting membrane (ILM), outer plexiform layer (OPL) and retinal pigment epithelial (RPE) boundaries were manually drawn for each of 19 raster SDOCT images. A computerized algorithm was used to calculate inner retinal (IRT= ILM to OPL distance) and outer retinal (ORT = outer nuclear layer to RPE distance) thickness values. Total retinal thickness (TRT) was calculated as the sum of IRT and ORT. Maps of IRT, ORT and TRT were generated and an average thickness for each of the nine ETDRS macular subfields was calculated. IRT, ORT and TRT values obtained in NPDR with CSDME, NPDR without CSDME and ME and normal eyes were compared using analysis of variance (ANOVA).

Results: : Thickness data were obtained in 26 NPDR with CSDME (age: 65 +/- 8 years), 8 NPDR without CSDME (age: 66 +/- 7 years) and 15 normal (age: 52 +/- 6 years) eyes. Overall, retinal thickness was lowest in normal eyes and highest in NPDR with CSDME eyes. In the foveal area, TRT was 337 +/- 14µ, 276 +/- 25µ, and 266 +/- 18µ in NPDR with CSDME, NPDR without CSDME, and normal eyes, respectively. Statistically significant differences among the 3 groups were found for IRT in the foveal area (p=0.03), ORT in temporal parafoveal area (p=0.04) and TRT in foveal, temporal parafoveal and perifoveal areas (p≤0.02).

Conclusions: : In NPDR with CSDME eyes, inner retinal thickening is responsible for the majority of retinal thickening. In both NPDR with and without CSDME, temporal macular thickening was found as compared with controls.

Keywords: diabetic retinopathy • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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