April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Retinal Nerve Fiber Layer Evaluation in Demyelinating Diseases with Spectral-Domain Optical Coherence Tomography and Scanning Laser Polarimetry
Author Affiliations & Notes
  • Fabiana F. Goncalves
    Ophthalmology,
    Universidade Federal de Sao Paulo, Sao Paulo, Brazil
  • Andre S. Camargo
    Ophthalmology,
    Universidade Federal de Sao Paulo, Sao Paulo, Brazil
  • Eric P. Andrade
    Ophthalmology,
    Universidade Federal de Sao Paulo, Sao Paulo, Brazil
  • Luiz Filipe A. Lucatto
    Ophthalmology,
    Universidade Federal de Sao Paulo, Sao Paulo, Brazil
  • Luiz Alberto S. Melo Jr
    Ophthalmology,
    Universidade Federal de Sao Paulo, Sao Paulo, Brazil
  • Denis B. Bichuetti
    Neurology,
    Universidade Federal de Sao Paulo, Sao Paulo, Brazil
  • Enedina Maria L. Oliveira
    Neurology,
    Universidade Federal de Sao Paulo, Sao Paulo, Brazil
  • Tiago A. Macruz
    Universidade Federal de Sao Paulo, Sao Paulo, Brazil
  • Ivan M. Tavares
    Ophthalmology,
    Universidade Federal de Sao Paulo, Sao Paulo, Brazil
  • Footnotes
    Commercial Relationships  Fabiana F. Goncalves, None; Andre S. Camargo, None; Eric P. Andrade, None; Luiz Filipe A. Lucatto, None; Luiz Alberto S. Melo Jr, None; Denis B. Bichuetti, None; Enedina Maria L. Oliveira, None; Tiago A. Macruz, None; Ivan M. Tavares, None
  • Footnotes
    Support  CNPq, Ministry of Sciences and Technology, Brazil and CAPES, Ministry of Education
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3658. doi:
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      Fabiana F. Goncalves, Andre S. Camargo, Eric P. Andrade, Luiz Filipe A. Lucatto, Luiz Alberto S. Melo Jr, Denis B. Bichuetti, Enedina Maria L. Oliveira, Tiago A. Macruz, Ivan M. Tavares; Retinal Nerve Fiber Layer Evaluation in Demyelinating Diseases with Spectral-Domain Optical Coherence Tomography and Scanning Laser Polarimetry. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3658.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To demonstrate whether retinal nerve fiber layer (RNFL) thicknessmeasured by spectral-domain optical coherence tomography (SD-OCT)and scanning laser polarimetry (SLP) is a potential biomarkerfor demyelinating diseases (multiple sclerosis [MS] and neuromyelitisoptica [NMO]).

 
Methods:
 

In this cross-sectional study, patients with MS and NMO diagnosedaccording to clinical and neuroimaging criteria as well as healthyindividuals were recruited. Eyes with a recent clinical diagnosisof optic neuritis (less than six months), glaucoma, optic neuropathy(other than MS and NMO-related optic neuritis), or other relevantretinal and/or optic nerve disease were excluded. The eyes hadthe parapapillary RNFL thickness measured by SD-OCT, using theSpectralis (software version 4.0, Heidelberg Engineering, Dossenheim,Germany), and by SLP, using the GDxVCC (software version 5.3.3,Carl Zeiss Meditec Inc., Dublin, CA).

 
Results:
 

Fifty-four eyes of 27 patients with MS, 9 eyes of 5 patientswith NMO, and 45 eyes of 23 healthy individuals were included.RNFL measurements were compared between groups in Table 1. Thepercentage of abnormal results is shown in Table 2.

 
Conclusions:
 

The RNFL is affected in MS and NMO. SD-OCT retinal imaging mayrepresent a high-resolution, objective, noninvasive, and easilyquantifiable in vivo biomarker of MS and NMO.  

 

 
Keywords: nerve fiber layer • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • neuro-ophthalmology: diagnosis 
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