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Fabiana F. Goncalves, Andre S. Camargo, Eric P. Andrade, Luiz Filipe A. Lucatto, Luiz Alberto S. Melo Jr, Denis B. Bichuetti, Enedina Maria L. Oliveira, Tiago A. Macruz, Ivan M. Tavares; Retinal Nerve Fiber Layer Evaluation in Demyelinating Diseases with Spectral-Domain Optical Coherence Tomography and Scanning Laser Polarimetry. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3658.
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To demonstrate whether retinal nerve fiber layer (RNFL) thicknessmeasured by spectral-domain optical coherence tomography (SD-OCT)and scanning laser polarimetry (SLP) is a potential biomarkerfor demyelinating diseases (multiple sclerosis [MS] and neuromyelitisoptica [NMO]).
In this cross-sectional study, patients with MS and NMO diagnosedaccording to clinical and neuroimaging criteria as well as healthyindividuals were recruited. Eyes with a recent clinical diagnosisof optic neuritis (less than six months), glaucoma, optic neuropathy(other than MS and NMO-related optic neuritis), or other relevantretinal and/or optic nerve disease were excluded. The eyes hadthe parapapillary RNFL thickness measured by SD-OCT, using theSpectralis (software version 4.0, Heidelberg Engineering, Dossenheim,Germany), and by SLP, using the GDxVCC (software version 5.3.3,Carl Zeiss Meditec Inc., Dublin, CA).
Fifty-four eyes of 27 patients with MS, 9 eyes of 5 patientswith NMO, and 45 eyes of 23 healthy individuals were included.RNFL measurements were compared between groups in Table 1. Thepercentage of abnormal results is shown in Table 2.
The RNFL is affected in MS and NMO. SD-OCT retinal imaging mayrepresent a high-resolution, objective, noninvasive, and easilyquantifiable in vivo biomarker of MS and NMO.
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