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Olufemi Oderinlo, Adunola O. Ogunro, Adekunle O. Hassan; Optical Coherence Tomographic Determination Of Ganglion Cell Complex In Glaucoma And Macula Disease. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3661.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the differences between ganglion cell complex of primary open angle glaucoma and ocular disorders affecting the macula.
47 patients diagnosed with primary open angle glaucoma and 27 patients with macula diseases of different etiology were enrolled in this study. All patients underwent direct ganglion cell (GCC) analysis with the Optical Coherence Tomographic scans using the Optovue Fourier Domain RTVue-version. Comparism of the average GCC thickness, Focal loss volume (FLV%) and the Global loss volume (GLV) were made between the two groups.
A total of 74 eyes of 74 patients were included in the study. 48 males and 26 females with mean age of 53.8 ± 11.3 among glaucoma patients and 59.8 ± 9.8 among patients with macula disease. 18.5 % (5 eyes)of eyes with macula disease had macula oedema secondary to retina vein occlusions, 18.5 % (5 eyes) had macula oedema secondary to diabetic retinopathy and 18.5 % (5 eyes)had wet age related macular degeneration. A further 26 % (7 eyes) had macula holes and 14.8% (4 eyes) had polypoidal choroidal vasculopathy affecting the macular. 3.7%(1 eye)had an old macular toxoplasma scar. Eyes with macula disease (33.3%) and eyes with glaucoma (42.6%) had abnormal GCC parameters, however, mean average GCC values were significantly higher in eyes with macular disease (87.50 ± 20.73) when compared with eyes with glaucoma (76.55 ± 12.51) (p=0.01). A significantly higher percentage of eyes with macula disease (43.3%) had GLV values within normal when compared with eyes with glaucoma (21.3%) (p=0.03). Abnormal FLV values were seen in both eyes with macular disease (83.3%) and eyes with glaucoma (80.9%) but the differences were not of statistical significance (p= 0.24).
This pilot study demonstrated abnormal OCT GCC values in eyes with glaucoma as well as eyes with macula disease, however, eyes with macula disease have significantly higher mean average GCC parameters but GLV parameters that were within normal values.
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