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Michele Reibaldi, Alfredo Reibaldi, Teresio Avitabile, Maurizio Giacinto Uva, Antonio Longo, Silvio Zagari, Marco Zagari, Marco La Bruna, Mario Toro, Andrea Russo; Reproducibility Of Retinal Nerve Fiber Layer Thickness Measurements Using Spectral Domain Optical Coherence Tomography In Eyes With Keratoconus. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3664.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the reproducibility of the peripapillary retinal nerve fiber layer (RNFL) thickness measurements obtained by Spectralis spectral domain optical coherence tomography (OCT) in normal eyes and eyes with keratoconus.
Peripapillary RNFL thickness was evaluated with Spectralis spectral domain OCT (Heidelberg Engineering, Heidelberg, Germany). Measurements were repeated 3 times during the same visit using the follow-up function. One eye of each participant was randomly selected for statistical analysis. Reproducibility was evaluated using within-subject standard deviation (Sw), coefficient of variation (CV), and intraclass correlation coefficient (ICC).
Forty normal eyes and forty eyes with keratoconus were included in the study. The RNFL thickness overall global CV was 1.37% in normal eyes and 2.10% in eyes with keratoconus. The RNFL thickness overall global ICC (95% CI) was 0.987 (0,973-0,994) in normal eyes and 0.964 (0,926-0,984) in eyes with keratoconus. The RNFL thickness overall global Sw ±1.96 standard error was 1,66±0,22 µm in normal eyes and 2,18±0,21 µm in eyes with keratoconus
Spectralis OCT shows a very good reproducibility compared with normal eyes for measuring the peripapillary RNFL thickness in keratoconus eyes
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