April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Repeatability and Variability of Retinal Nerve Fiber Layer Measurements in Healthy Subjects with Three Spectral Domain Optical Coherence Tomographs
Author Affiliations & Notes
  • Alexander A. Shpak
    Clin & Functional Diag, S Fyodorov Eye Microsurgery Complex, Moscow, Russian Federation
  • Svetlana N. Ogorodnikova
    Clin & Functional Diag, S Fyodorov Eye Microsurgery Complex, Moscow, Russian Federation
  • Footnotes
    Commercial Relationships  Alexander A. Shpak, None; Svetlana N. Ogorodnikova, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3670. doi:
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      Alexander A. Shpak, Svetlana N. Ogorodnikova; Repeatability and Variability of Retinal Nerve Fiber Layer Measurements in Healthy Subjects with Three Spectral Domain Optical Coherence Tomographs. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3670.

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Abstract

Purpose: : to evaluate the intrasession repeatability and variability of retinal nerve fiber layer (RNFL) measurements in healthy subjects using 3 instruments: Cirrus HD-OCT (Carl Zeiss Meditec), SOCT Copernicus HR (Optopol) and 3D OCT-1000 (Topcon).

Methods: : The RNFL thickness was measured by Cirrus HD-OCT and SOCT Copernicus HR in 25 healthy volunteers. Each person was examined by both instruments in one session. One experienced operator took 2 measurements with each instrument. In another similar group of 25 healthy subjects the RNFL measurements were performed by 3D OCT-1000. The same operator took 2 measurements in one session. The repeatability was evaluated by J.M.Bland-D.G.Altman analysis (1996). Within-subject coefficients of variation were calculated using J.M.Bland method.

Results: : All instruments demonstrated similar intrasession repeatability: 3.21 µm for Cirrus HD-OCT, 3.57 µm for SOCT Copernicus HR and 4.20 µm for 3D OCT-1000 (the differences were not statistically significant). Within-subject coefficient of variation was equal for SOCT Copernicus HR and 3D OCT-1000 (1.40±0.20%). Cirrus HD-OCT showed slight but insignificant tendency for lower variability (within-subject coefficient of variation was 1.23±0.17%).

Conclusions: : All three spectral domain optical coherence tomographs demonstrated good intrasession repeatability and low variability of RNFL measurements.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • nerve fiber layer 
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