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Ahsen Hussain, James Hare, Alexandros Stangos, Yalin Zheng, Jayashree Sahni; Feature Analysis of Spectral-Domain Optical Coherence Tomography in Central Serous Chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3686.
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To qualitatively and quantitatively analyse Spectralis OpticalCoherence Tomography (OCT) features in patients with treatment-naïveCentral Serous Chorioretinopathy (CSCR) and correlate morphometricfindings with vision and duration of symptoms.
Prospective, observational study. Data was collected for LogMARvisual acuity and duration of symptoms (<3 months= acute;>3 months=chronic).OCT scans passing through the fovea wereanalysed for presence or absence of:• subretinal fluid(SRF)• intraretinal fluid (IRF)• pigment epithelialdetachment (PED)• irregularities of the inner boundaryof SRF• reflective irregularities of the photoreceptorinner/outer segment layer.• integrity of the external limitingmembrane (ELM)• central foveal thickness (CFT) includingSRF• SRF cross-sectional area• photoreceptor heightRetinallayers, cross-sectional area of fluid and foveal height weremarked using ImageJ 1.43 (NIH, Maryland, USA). and analysedby our proprietary software to calculate the thickness of eachretinal layer at the fovea.
Data was collected from 26 eyes of 25 patients. Two eyes wereasymptomatic; 11 had acute symptoms, 12 had chronic symptoms.Data for one patient was unavailable.See Results Table Images1&2
Feature analysis of Spectralis OCT images has identified severalhallmark microstructural abnormalities in patients with CSCR.However, morphometric changes on OCT did not appear to correlatewith clinical presentation in CSCR.
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