Purpose:
To qualitatively and quantitatively analyse Spectralis OpticalCoherence Tomography (OCT) features in patients with treatment-naïveCentral Serous Chorioretinopathy (CSCR) and correlate morphometricfindings with vision and duration of symptoms.
Methods:
Prospective, observational study. Data was collected for LogMARvisual acuity and duration of symptoms (<3 months= acute;>3 months=chronic).OCT scans passing through the fovea wereanalysed for presence or absence of:• subretinal fluid(SRF)• intraretinal fluid (IRF)• pigment epithelialdetachment (PED)• irregularities of the inner boundaryof SRF• reflective irregularities of the photoreceptorinner/outer segment layer.• integrity of the external limitingmembrane (ELM)• central foveal thickness (CFT) includingSRF• SRF cross-sectional area• photoreceptor heightRetinallayers, cross-sectional area of fluid and foveal height weremarked using ImageJ 1.43 (NIH, Maryland, USA). and analysedby our proprietary software to calculate the thickness of eachretinal layer at the fovea.
Results:
Data was collected from 26 eyes of 25 patients. Two eyes wereasymptomatic; 11 had acute symptoms, 12 had chronic symptoms.Data for one patient was unavailable.See Results Table Images1&2
Conclusions:
Feature analysis of Spectralis OCT images has identified severalhallmark microstructural abnormalities in patients with CSCR.However, morphometric changes on OCT did not appear to correlatewith clinical presentation in CSCR.
Keywords: retina • imaging/image analysis: clinical • chorioretinitis