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Gaetano Zinzanella, Angelo M. Minnella, Maria Cristina Savastano, Giacomilde Mazzone, Matteo Federici, Mariangela Gari, Lucilla Barbano, Benedetto Falsini, Emilio Balestrazzi; Spectral Domain-optical Coherence Tomography In Irvine-gass Syndrome. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3696.
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To report morphological evaluation up to 12-months by spectral domain-optical coherence tomography (SD-OCT) in patients with cystic macular edema (CME) after cataract surgery (Irvine-Gass syndrome) receiving systemic therapy with oral acetazolamide and topical indomethacin.
Fifteen eyes with Irvine-Gass syndrome were evaluated. An observational period of 3 months after surgery was considered before starting therapy. In this interventional case series study patients underwent ocular ophthalmological examinations. Repeated measures analysis of variance (ANOVA) was used to compare mean values
Mean (±SD) central macular thickness by SD-OCT was 530 (±98.1), 385.6 (±55.1), 339 (±32.3) and 316.2 (±27.0) µm at baseline, 3, 6, and 12 months of follow-up respectively (P<0.001). Eyes with interruption of inner segment/outer segment (IS/OS) junction at baseline (20%) showed a persistent damage of the photoreceptor junction and not complete visual acuity restoration or patient complains at the end of follow-up. Mean (±SD) BSCVA was 0.6 (±0.2), 0.2 (±0.1), 0.16 (±0.1) and 0.09 (±0.07) logMAR at baseline, 3, 6, and 12-month follow-up respectively (P< 0.001)
SD-OCT detects retinal findings including photoreceptor IS/OS junction changes in patients with Irvine-Gass syndrome. Oral acetazolamide and topical indomethacin could be recommended as an efficacious therapy of this disease
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