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Aoi Komuro, Norihiko Yokoi, Rieko Sakai, Shigeru Kinoshita; Tear Osmolarity Measurement Using The TearlabTM Osmolarity System In Patients With Short Breakup Time Dry Eye. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3789.
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Short breakup time dry eye (SBUTDE) is a disorder which is characterized by a short fluorescein breakup time (FBUT) and severe ocular symptoms. SBUTDE does not generally accompany tear deficiency and produces minimal ocular surface damage. In this study, we evaluated tear osmolarity using the TearLabTM Osmolarity System (TearLab Corp., San Diego, CA) in SBUTDE and compared it with a normal control group and an aqueous tear-deficient dry eye (ADDE) group.
Seven eyes of SBUTDE (mean age: 46.1±3.9 years), 19 eyes of ADDE (67.7±5.1 years), and 7 normal control eyes (42.6±13.8yrs) were enrolled in this study. Tear osmolarity was measured using TearLabTM Osmolarity System and the radius of the lower central tear meniscus curvature (R, mm) which correlates with tear volume was measured by video meniscometry. The correlation between the osmolarity and the tear meniscus curvature was then evaluated.
Tear osmolarity values were 305.3±16.3 Osmol/L in SBUTDE group, 296.7±16.4 Osmol/L in the aqueous tear-deficient dry eye group, and 290.2±7.8 Osmol/L in the control group. Osmolarity in SBUTDE group was significantly higher than in the control group (p=0.0067). There was no significant difference in osmolarity between SBUTDE and ADDE group. There was no significant correlation between tear osmolarity and tear meniscus curvature (r2=0.042).
The findings of this study show that the measurement of tear osmolarity may be useful for understanding the pathogenesis of SBUTDE.
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