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Maria J. Perez Carrasco, Sr., Luis L. Lobato-Rincon, Jose G. Ramirez-Mercado, Maria del Carmen Cabanillas-Campos, Gonzalo Alvarez-Rementeria, Antonio Langa-Moraga, Celia Sanchez-Ramos, Sr.; Effects Of Alcohol On The Mesopic Pupil Reflex Produced In Response To Coloured Flash Stimuli. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4909.
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To examine the use of dynamic pupillometry as a method of detecting alcohol levels, we assessed the different stages of the pupil reflex produced in response to coloured stimuli before and after alcohol intake.
Using the Power Refractor II Pupillometer (Plusoptix, Germany) two subjects were examined before and after alcohol intake in mesopic conditions and a meter away. After a 15-minute adaptation period to the dark, white and blue flashes were delivered through a neutral density filter (12 lux) and 450 nm interference filter (2-5 lux) respectively, separated by 2 minutes in random order. The stimulation time was 1/3500 s per flash, and the light source was located 2 meters away from the examinees. Six binocular measurements were obtained in each subject per filter, to give 24 measurements per subject in the two sessions. For each measurement, the variables prestimulus mydriasis, latency, amplitude, speed and acceleration, were computed through a parser.
Mean measurements (n=24) obtained respectively before and after alcohol intake were: prestimulus mydriasis (mm): white filter (WF) 5.14/5.86, blue filter (BF) 5.04/5.95; latency (ms): WF 283.45/232, BF 289 /336.67; amplitude (mm): WF 1.79/1.79, BF 1.08/0.95; speed (mm/ms): WF 0.003/0.002, BF 0.003/0.002; and acceleration (mm/ms2): WF 6.9x10-6/5.3x10-6, BF 10x10-6/8.1x10-6.
Mesopic dynamic pupillometry served to detect small differences in the different stages of the pupil reflex produced in response to alcohol intake.
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