April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Magnetic Tamponade for Retinal Detachment: Superparamagnetic Nanoparticles
Author Affiliations & Notes
  • Mario J. Saravia
    Retina, Hospital Universitario Austral, Pilar-Buenos Aires, Argentina
  • Roberto Zysler
    Magnetismo, CNEA, Bariloche, Argentina
  • Pablo Gurman
    UBA, Buenos Aires, Argentina
  • Orlando Auciello
    CNSM, Argonne National Laboratory, Chicago, Illinois
  • Ezequiel Rosendi, III
    Retina, Hospital Lagleyze, Buenos Aires, Argentina
  • Alejandro Berra
    Laboratorio de Investigacion Ocular, Universidad de Buenos Aires, Buenos Aires, Argentina
  • Footnotes
    Commercial Relationships  Mario J. Saravia, patent application (P); Roberto Zysler, patent application (P); Pablo Gurman, patent application (P); Orlando Auciello, patent application (P); Ezequiel Rosendi, III, None; Alejandro Berra, patent application (P)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 4912. doi:
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    • Get Citation

      Mario J. Saravia, Roberto Zysler, Pablo Gurman, Orlando Auciello, Ezequiel Rosendi, III, Alejandro Berra; Magnetic Tamponade for Retinal Detachment: Superparamagnetic Nanoparticles. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4912.

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      © ARVO (1962-2015); The Authors (2016-present)

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To demonstrate safety and efficacy of nanoparticles with superparamagnetic properties injected during vitrectomy as a tamponade to reattach the retina in a retinal detachment model.


Right eyes of ten NZ rabitts were operated. An external magnet sutured on superior sclera was implanted in each right eye. Vitrectomy was performed in experimental eyes. A retinal tear was generated with a 23G cannula in a place correspondent to the external implant location, and saline solution was injected through the tear until the retina was detached at least one quadrant. Nanoparticles sized under 20 nm were obtained with a caracterization such that they behave as superparamagnetic ( magnetic behavior only under influence of a magnetic camp) . Superparamagnetic nanoparticles (SPMNP) 10% were mixed with 1% hyaluronic acid. SPMNP were injected around the lesion in 7 eyes. Three eyes remained without injection for control. Three additional rabbits were injected without surgery to evaluate inflammatory response to SPMNP. Images of the fundus and OCT were obtained at days 3, 7, 14 and 21 after surgery. The 13 rabitts were sacrified on day 21, and eyes were fixed for retinal histology with H-E to assess signs of inflammation, toxicity or damage.


Retina was attached in the 7 eyes with SPMNP. Retinas remained detached in three eyes without SPMNP. Neither signs of cataract, inflammation nor toxicity were recorded in the histology of the three groups. No SPMNP were detected beyond internal limiting membrane. No signs of structural damage were observed.


Magnetic tamponade with SPMNP may be a safe and efficacious treatment for retinal detachment at a preliminar preclinical fase in animal model.  

Keywords: retinal detachment • vitreous substitutes • vitreoretinal surgery 

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