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Aize Kijlstra, Lukas J. Ricker, Wilco de Jager, Fred Hendrikse, Ellen C. La Heij; Adipokine Levels in Subretinal Fluid from Patients with Rhegmatogenous Retinal Detachment. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4922.
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To determine the possible involvement of adipokines in the future development of proliferative vitreoretinopathy (PVR) following reattachment surgery for rhegmatogenous retinal detachment (RRD).
A multiplex immunoassay was used to measure 6 different adipokines in 75 subretinal fluid samples collected during reattachment surgery for primary RRD. Twenty-one patients who developed a redetachment due to postoperative PVR after scleral buckling surgery (PVR group) were compared with age-, sex-, and storage-time-matched RRD samples from 54 patients with an uncomplicated postoperative course (RRD group).
Detectable levels of adiponectin, adipisin, cathepsin S, chemerin, and leptin were determined in all 75 samples investigated, whereas for tissue inhibitor of metalloproteinase (TIMP)-1, 2/21 (9.5%) PVR samples and 21/54 (38.9%) RRD samples were above the upper detection limit (P = 0.013). The median levels of adiponectin were significantly elevated in the PVR group (26877 pg/mL; range 7810 - 46132) as compared to the RRD group (17699 pg/mL; range 2300 - 38737) (P = 0.006). A highly significant difference was also noted for cathepsin S with median levels of 6119 pg/mL (range 2326 - 9453) in the PVR group and 4592 pg/mL in the RRD group (range 1230 - 10151) (P = 0.001). Furthermore, we found a 2-fold elevation of median leptin levels in patients who developed postoperative PVR (2357 pg/mL; range 818 - 13067) as compared to RRD patients with an uncomplicated postoperative course (1136 pg/mL; range 694 - 7397) (P = 0.041). There were no significant differences in levels of adipsin (P = 0.915) and chemerin (P = 0.351) between both groups. In contrast, median levels of TIMP-1 were significantly lower in the PVR group (14401 pg/mL; range 8724 - >28000) than in the RRD group (16356 pg/mL; range 8581 - >28000) (P = 0.044). Of all adipokines investigated, logistic regression analysis showed that adiponectin was the exclusive predictor of the development of redetachment due to PVR after scleral buckling surgery (P = 0.003). We found that for each 10000 pg/mL increase in adiponectin content the probability of the occurrence of postoperative PVR increased with an odds ratio of 2.3.
Our findings indicate that an increased expression of adiponectin, cathepsin S, and leptin and a decreased expression of TIMP-1 at the time of primary retinal detachment surgery are associated with the future development of PVR.
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