April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Adipokine Levels in Subretinal Fluid from Patients with Rhegmatogenous Retinal Detachment
Author Affiliations & Notes
  • Aize Kijlstra
    Ophthalmology, University Eye Clinic Maastricht, Maastricht, The Netherlands
  • Lukas J. Ricker
    Ophthalmology, University Eye Clinic Maastricht, Maastricht, The Netherlands
  • Wilco de Jager
    Pediatric Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
  • Fred Hendrikse
    Ophthalmology, University Eye Clinic Maastricht, Maastricht, The Netherlands
  • Ellen C. La Heij
    Ophthalmology, University Eye Clinic Maastricht, Maastricht, The Netherlands
  • Footnotes
    Commercial Relationships  Aize Kijlstra, None; Lukas J. Ricker, None; Wilco de Jager, None; Fred Hendrikse, None; Ellen C. La Heij, None
  • Footnotes
    Support  This study was financially supported by the Algemene Nederlandse Vereniging ter Voorkoming van Blindheid.
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 4922. doi:
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      Aize Kijlstra, Lukas J. Ricker, Wilco de Jager, Fred Hendrikse, Ellen C. La Heij; Adipokine Levels in Subretinal Fluid from Patients with Rhegmatogenous Retinal Detachment. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4922.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To determine the possible involvement of adipokines in the future development of proliferative vitreoretinopathy (PVR) following reattachment surgery for rhegmatogenous retinal detachment (RRD).

Methods: : A multiplex immunoassay was used to measure 6 different adipokines in 75 subretinal fluid samples collected during reattachment surgery for primary RRD. Twenty-one patients who developed a redetachment due to postoperative PVR after scleral buckling surgery (PVR group) were compared with age-, sex-, and storage-time-matched RRD samples from 54 patients with an uncomplicated postoperative course (RRD group).

Results: : Detectable levels of adiponectin, adipisin, cathepsin S, chemerin, and leptin were determined in all 75 samples investigated, whereas for tissue inhibitor of metalloproteinase (TIMP)-1, 2/21 (9.5%) PVR samples and 21/54 (38.9%) RRD samples were above the upper detection limit (P = 0.013). The median levels of adiponectin were significantly elevated in the PVR group (26877 pg/mL; range 7810 - 46132) as compared to the RRD group (17699 pg/mL; range 2300 - 38737) (P = 0.006). A highly significant difference was also noted for cathepsin S with median levels of 6119 pg/mL (range 2326 - 9453) in the PVR group and 4592 pg/mL in the RRD group (range 1230 - 10151) (P = 0.001). Furthermore, we found a 2-fold elevation of median leptin levels in patients who developed postoperative PVR (2357 pg/mL; range 818 - 13067) as compared to RRD patients with an uncomplicated postoperative course (1136 pg/mL; range 694 - 7397) (P = 0.041). There were no significant differences in levels of adipsin (P = 0.915) and chemerin (P = 0.351) between both groups. In contrast, median levels of TIMP-1 were significantly lower in the PVR group (14401 pg/mL; range 8724 - >28000) than in the RRD group (16356 pg/mL; range 8581 - >28000) (P = 0.044). Of all adipokines investigated, logistic regression analysis showed that adiponectin was the exclusive predictor of the development of redetachment due to PVR after scleral buckling surgery (P = 0.003). We found that for each 10000 pg/mL increase in adiponectin content the probability of the occurrence of postoperative PVR increased with an odds ratio of 2.3.

Conclusions: : Our findings indicate that an increased expression of adiponectin, cathepsin S, and leptin and a decreased expression of TIMP-1 at the time of primary retinal detachment surgery are associated with the future development of PVR.

Keywords: retinal detachment • proliferative vitreoretinopathy • cytokines/chemokines 
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