April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Surgical Implantation of Newly Designed Subretinal Implant in Minipig Eyes
Author Affiliations & Notes
  • Jinghua Chen
    Ophthalmology, Mass Eye and Ear Infirmary, Boston, Massachusetts
  • Patrick Doyle
    Center for Innovative Visual Rehabilitation, VA Medical Center, Boston, Massachusetts
    Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts
  • Josy Dumser
    Ophthalmology, Mass Eye and Ear Infirmary, Boston, Massachusetts
  • Amir Marvasti
    Center for Innovative Visual Rehabilitation, VA Medical Center, Boston, Massachusetts
    Boston University School of Medicine, Boston, Massachusetts
  • Oscar Mendoza
    Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts
  • Marcus Gingerich
    Center for Innovative Visual Rehabilitation, VA Medical Center, Boston, Massachusetts
    Cornell Nanofabrication Facility, Ithaca, New York
  • Shawn Kelly
    Center for Innovative Visual Rehabilitation, VA Medical Center, Boston, Massachusetts
    Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts
  • Douglas Shire
    Center for Innovative Visual Rehabilitation, VA Medical Center, Boston, Massachusetts
    Cornell Nanofabrication Facility, Ithaca, New York
  • Joseph F. Rizzo, III
    Ophthalmology, Mass Eye and Ear Infirmary, Boston, Massachusetts
    Center for Innovative Visual Rehabilitation, VA Medical Center, Boston, Massachusetts
  • Footnotes
    Commercial Relationships  Jinghua Chen, None; Patrick Doyle, None; Josy Dumser, None; Amir Marvasti, None; Oscar Mendoza, None; Marcus Gingerich, None; Shawn Kelly, None; Douglas Shire, None; Joseph F. Rizzo, III, None
  • Footnotes
    Support  VA Grant C4266C, VA Grant A7078R, VA Grant C7055L, NIH Grant 1-R01-HL090856-01A1
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 4929. doi:
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      Jinghua Chen, Patrick Doyle, Josy Dumser, Amir Marvasti, Oscar Mendoza, Marcus Gingerich, Shawn Kelly, Douglas Shire, Joseph F. Rizzo, III; Surgical Implantation of Newly Designed Subretinal Implant in Minipig Eyes. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4929.

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Abstract 
 
Purpose:
 

This work is related to the efforts of the Boston Retinal Implant Project to develop a sub-retinal prosthesis to restore vision to the blind. This presentation summarizes the latest generation Boston retinal implant and its surgical results in minipig eyes.

 
Methods:
 

The latest generation Boston retinal implants were implanted into 3 minipig eyes via an ab externo method to study in vivo biocompatibility. Our inactive implants contain 2mm wide secondary power and data receiving coils, a 2.4mm thick hermetic case and a parylene coated 29 µm-thick, 4mm wide polyimide-based flexible electrode arrays. The spherically-molded coil has a inner diameter of 19.4 mm and a thickness of 0.18 mm. To prevent excessive bleeding, "controlled" systemic hypotension was introduced during insertion. A local retinal detachment was created after vitrectomy. The coils were sutured around the cornea and the hermetic cases were sutured onto sclera nasally. Electrode arrays were placed into subretinal space temporally with an ab externo method. Conjunctiva and the tenon were closed over the implant.

 
Results:
 

All 3 inactive implants were successfully implanted into 3 minipig eyes. One electrode array was implanted into the subretinal space. One electrode array was partially implanted into the subretinal space. The other surgery did not include the array implantation procedure. Two out of the 3 pigs showed very good tolerance of the device. One pig experienced erosion of the conjunctiva by the device.

 
Conclusions:
 

Our latest generation Boston retinal implant has a better biocompatibility in Yucatan minipig eyes with our modified surgical methods. More experiments will be done to improve the long term biocompatibility of our device.  

 
Keywords: vitreoretinal surgery • retinal detachment • neuro-ophthalmology: cortical function/rehabilitation 
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