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Ryuta Kimoto, Akira Hagiwara, Takeshi Sugawara, Shuichi Yamamoto; Electrophysiological Function Of Inner Retina In Patients With Retinitis Pigmentosa. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4989.
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To evaluate the relationship between the morphology and function of the inner retina in patients with retinitis pigmentosa (RP).
Fifty-four eyes of 33 RP patients whose visual acuities were better than 0.7 were studied. The ganglion cell complex (GCC) and the photoreceptor inner/outer segment (IS/OS) junction within the central 10 degrees were examined by spectral-domain OCT. We examined P1 and the multifocal photopic negative response (mfPhNR) of the mfERGs within the central 10 degrees to assess the function. Eyes were divided into three groups according to the length (l) of the IS/OS junction: Group A, l <1 mm; Group B, 1≤ l <3 mm; and Group C, l ≥3 mm.
The mean GCC thickness was 91±17 µm in Group A, 99±9 µm in Group B, and 120±14 µm in Group C. The GCC in Group C was significantly thicker (P<0.01). mfERGs were recordable in 2 eyes (29%) in Group A, 19 eyes (73%) in Group B, and 19 eyes (90%) in Group C. The mean P1 amplitude was 4.25±0.21 nV/deg2, 4.2±2.1 nV/deg2, and 7.5±3.6 nV/deg2 in the three groups, respectively, and the response was significantly larger in Group C (P<0.01). The mean mfPhNR amplitude was 2.75±2.75 nV/deg2, 3.9±2.4 nV/deg2, and 5.0±2.9 nV/deg2, respectively. The mean mfPhNR/P1 ratio was 0.66±0.68, 1.0±0.63, and 0.80±0.56 for the three groups. There was no significant difference in either PhNR amplitude or PhNR/P1 ratio among the three groups. There was a significant correlation between the GCC thickness and the mfPhNR amplitude in Group B (P=0.004), but the correlations were not significant in the other two groups.
These results indicate that the thinning of inner retina is significantly correlated with the shortening of IS/OS junction. The amplitudes of P1 and mfPhNR were significantly correlated with the length of IS/OS, however the mfPhNR was not significantly correlated with the thickness of the inner retina.
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