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Pooya Banapour, Jeffrey M. Liebmann, Christopher A. Girkin, Mauro T. Leite, Linda M. Zangwill, Robert N. Weinreb, Pamela A. Sample, Felipe M. Medeiros; African Descent And Glaucoma Evaluation Study (ADAGES): The Relationship Between Central Corneal Thickness And Measures Of Disease Severity In African Descendents And European Descendents With Glaucoma. Invest. Ophthalmol. Vis. Sci. 2011;52(14):5025.
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To evaluate the relationship between central corneal thickness (CCT) and glaucoma severity in subjects of African descent (AD) and European descent (ED).
1194 eyes (639 in ED, 555 in AD) of 834 glaucoma patients and glaucoma suspects recruited from the Diagnostic Innovations in Glaucoma Study (DIGS) and from the African Descent and Glaucoma Evaluation Study (ADAGES) were included in this cross-sectional study. Participants underwent imaging with the GDx with enhanced corneal compensation (ECC) and the Heidelberg retina tomograph (HRT). Disease severity was measured by visual field mean deviation (MD), global retinal nerve fiber layer (RNFL) thickness and rim area (RA). Univariable and multivariable regression models were built to evaluate the associations between disease severity and CCT in AD and ED.
AD participants had significantly thinner CCT (533µm vs 555µm), lower MD (-3.37dB vs. -2.51dB), thinner RNFL (47.06µm vs 48.18µm) and larger RA (1.34mm2 vs 1.21mm2) and disc area (DA) (2.20mm2 vs 1.88mm2) compared to ED participants (all P<0.007). A significant relationship was found between CCT and measures of disease severity in both racial groups (all P<0.04). Each 40µm decrease in CCT resulted in a decrease in MD of 1.22dB in ED and 0.62dB in AD (P=0.068), a decrease in RA of 0.07mm2 in ED and 0.03mm2 in AD (P=0.234) and a decrease in RNFL thickness of 2.4µm in ED and 1.1µm in AD (P=0.045). After adjusting for CCT, age, DA and IOPmax, no significant difference was found between races for measures of disease severity.
CCT was significantly associated with measures of disease severity in AD and ED participants. After adjustment for CCT, age, DA and IOPmax, no significant differences in measures of disease severity between the two racial groups were observed.
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