April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Association Of The Metabolic Syndrome With Ocular Hypertension And Open-angle Glaucoma: The Alienor Study
Author Affiliations & Notes
  • Cecile DelCourt
    Univ Victor Segalen Bordeaux 2, INSERM, U897, Bordeaux, France
  • Cédric Schweitzer
    Ophthalmology, Hopital Pellegrin, Bordeaux, France
  • Florence Malet
    Ophthalmology, Hopital Pellegrin, Bordeaux, France
  • Marie-Noelle Delyfer
    Univ Victor Segalen Bordeaux 2, INSERM, U897, Bordeaux, France
    Ophthalmology, Hopital Pellegrin, Bordeaux, France
  • Jean-Francois Korobelnik
    Univ Victor Segalen Bordeaux 2, INSERM, U897, Bordeaux, France
    Ophthalmology, Hopital Pellegrin, Bordeaux, France
  • Marie-Bénédicte Rougier
    Ophthalmology, Hopital Pellegrin, Bordeaux, France
  • Melanie Le Goff
    Univ Victor Segalen Bordeaux 2, INSERM, U897, Bordeaux, France
  • Jean-François Dartigues
    Univ Victor Segalen Bordeaux 2, INSERM, U897, Bordeaux, France
  • Pascale Barberger-Gateau
    Univ Victor Segalen Bordeaux 2, INSERM, U897, Bordeaux, France
  • Joseph Colin
    Ophthalmology, Hopital Pellegrin, Bordeaux, France
  • Footnotes
    Commercial Relationships  Cecile DelCourt, None; Cédric Schweitzer, None; Florence Malet, None; Marie-Noelle Delyfer, None; Jean-Francois Korobelnik, None; Marie-Bénédicte Rougier, None; Melanie Le Goff, None; Jean-François Dartigues, None; Pascale Barberger-Gateau, None; Joseph Colin, None
  • Footnotes
    Support  Laboratoires Théa
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 5028. doi:
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      Cecile DelCourt, Cédric Schweitzer, Florence Malet, Marie-Noelle Delyfer, Jean-Francois Korobelnik, Marie-Bénédicte Rougier, Melanie Le Goff, Jean-François Dartigues, Pascale Barberger-Gateau, Joseph Colin; Association Of The Metabolic Syndrome With Ocular Hypertension And Open-angle Glaucoma: The Alienor Study. Invest. Ophthalmol. Vis. Sci. 2011;52(14):5028.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To study the associations of ocular hypertension (OHT) and open-angle glaucoma (OAG) with the different components of the metabolic syndrome.

Methods: : The Alienor Study is a population-based epidemiological study on age-related eye diseases. 963 residents of Bordeaux (France), aged 73 years or more, had an eye examination in 2006-2008. Glaucoma was classified according to the criteria of the ISGEO group. Vertical Cup:disc ratio (VCDR) and neuroretinal rim width:disc ratio (RDR) were measured from non-mydriatic digital colour photographs centred on the optic disc. Subjects were considered as affected by glaucoma when they combined structural (VCDR >=0.7 and/or asymmetry of VCDR >=0.2 and/or RDR<=0.1) and functional (visual field with a group of three non borderline points with p<0.01 of which at least one with p<0.005) evidence. We also classified five cases which did not completely meet these criteria (category 2 and 3 diagnosis of ISGEO). All cases were OAG. OHT was defined as intraocular pressure> 21 mmHg and/or current use of IOP-lowering therapy, in the absence of OAG. Components of the metabolic syndrome were measured from measurements performed in 1999-2001, classified according to the NCEP criteria. Associations of OHT and OAG with components of the metabolic syndrome were assessed using generalized estimating equations (GEE) logistic regressions.

Results: : Of 963 subjects, 833 had complete data, representing 1666 gradable eyes. After adjustment for age and gender, elevated fasting glycemia (fasting blood glucose >6.1 mmol/l and/or anti-diabetic therapy) was associated with a 2-fold increased risk for OAG (OR=2.40, 95 % confidence interval (CI): 1.08-5.35, p=0.03). Association with OHT was in the same direction, but did not reach statistical significance (OR=1.48, 95 % CI: 0.83-2.66, p=0.19). Other components of the metabolic syndrome (hypertension, waist circumference, plasma HDL-cholesterol, plasma triglycerides) were not significantly associated with OHT or glaucoma. Overall, the metabolic syndrome was not significantly associated with OAG or OHT (OR=1.23, 95 % CI: 0.54-2.79, p=0.62 and OR=1.20, 95 % CI: 0.72-2.01, p=0.49, respectively).

Conclusions: : In the present study, OAG was associated with elevated fasting glycemia, but not other components of the metabolic syndrome.

Keywords: clinical (human) or epidemiologic studies: risk factor assessment • metabolism • diabetes 
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