April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Association of Ocular Perfusion Pressure Status with Open-Angle Glaucoma in the Thessaloniki Eye Study
Author Affiliations & Notes
  • Fotis Topouzis
    A Department of Ophthalmology, Aristotle Univ of Thessaloniki, Thessaloniki, Greece
  • M R. Wilson, III
    Chancellor's Office, University of Colorado Denver, Denver, Colorado
  • Alon Harris
    Ophthalmology, Indiana Univ Sch of Medicine, Indianapolis, Indiana
  • Panagiota Founti
    A Department of Ophthalmology, Aristotle Univ of Thessaloniki, Thessaloniki, Greece
  • Fei Yu
    Ophthalmology, Jules Stein Eye Institute, UCLA, Los Angeles, California
  • Eleftherios Anastasopoulos
    A Department of Ophthalmology, Aristotle Univ of Thessaloniki, Thessaloniki, Greece
  • Theofanis Pappas
    A Department of Ophthalmology, Aristotle Univ of Thessaloniki, Thessaloniki, Greece
  • Archimidis Koskosas
    A Department of Ophthalmology, Aristotle Univ of Thessaloniki, Thessaloniki, Greece
  • Aggeliki Salonikiou
    A Department of Ophthalmology, Aristotle Univ of Thessaloniki, Thessaloniki, Greece
  • Anne L. Coleman
    Ophthalmology, Jules Stein Eye Institute, UCLA, Los Angeles, California
  • Footnotes
    Commercial Relationships  Fotis Topouzis, None; M. R. Wilson, III, None; Alon Harris, None; Panagiota Founti, None; Fei Yu, None; Eleftherios Anastasopoulos, None; Theofanis Pappas, None; Archimidis Koskosas, None; Aggeliki Salonikiou, None; Anne L. Coleman, None
  • Footnotes
    Support  International Glaucoma Association, London, UK; UCLA Center for Eye Epidemiology, Los Angeles, CA; Health Future Foundation, Creighton University, Omaha, NE; Texas Tech University Health Sciences Cent
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 5029. doi:
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      Fotis Topouzis, M R. Wilson, III, Alon Harris, Panagiota Founti, Fei Yu, Eleftherios Anastasopoulos, Theofanis Pappas, Archimidis Koskosas, Aggeliki Salonikiou, Anne L. Coleman; Association of Ocular Perfusion Pressure Status with Open-Angle Glaucoma in the Thessaloniki Eye Study. Invest. Ophthalmol. Vis. Sci. 2011;52(14):5029.

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Abstract

Purpose: : To investigate the association of open-angle glaucoma (OAG) with ocular perfusion pressures (PP) status (PP level with and without antihypertensive treatment [anti-HTN]) in the Thessaloniki Eye Study (TES).

Methods: : TES is a cross sectional population-based study of chronic eye diseases in subjects over 60 yrs in Thessaloniki, Greece. Among 2261 clinic-visits, 135 OAG cases were identified. Diastolic PP (DPP) and systolic PP (SPP) were calculated for all TES participants. Subjects were divided into 6 groups: low DPP ( less than 20th percentile) with (n=234) or without (n=214) anti-HTN, median DPP ( 20th-80th percentile) with (n=710) or without (n=640) anti-HTN, and high DPP ( more than 80th percentile) with (n=268) or without (n=185) anti-HTN. Subjects were similarly divided into 6 groups of SPP status respectfully. Percentages of OAG in groups were compared using logistic regression models with median DPP and median SPP without anti-HTN groups as references. Adjustments were made for age, gender and vascular factors identified as risk factors for OAG in a previous analysis (coronary artery bypass or vascular surgery and diabetes treated with insulin).

Results: : The 20th and 80th percentiles for DPP were 58.5mmHg and 79mmHg respectively; for SPP they were 110mmHg and 147.5mmHg respectively. Low DPP with anti-HTN group presented with statistically significantly higher odds for OAG compared to the reference group (Odds Ratio, 2.02, 95% Confidence Interval, 1.16 - 3.52, p=0.013). Low DPP without anti-HTN, high DPP with or without anti-HTN and median DPP with anti-HTN groups were not associated with OAG. SPP status was not associated with OAG.

Conclusions: : This is the first study reporting that low DPP is associated with increased likelihood for OAG only in subjects receiving anti-HTN, while low DPP in subjects without anti-HTN is not associated with OAG.

Keywords: clinical (human) or epidemiologic studies: risk factor assessment • optic disc • optic flow 
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