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Fotis Topouzis, M R. Wilson, III, Alon Harris, Panagiota Founti, Fei Yu, Eleftherios Anastasopoulos, Theofanis Pappas, Archimidis Koskosas, Aggeliki Salonikiou, Anne L. Coleman; Association of Ocular Perfusion Pressure Status with Open-Angle Glaucoma in the Thessaloniki Eye Study. Invest. Ophthalmol. Vis. Sci. 2011;52(14):5029.
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To investigate the association of open-angle glaucoma (OAG) with ocular perfusion pressures (PP) status (PP level with and without antihypertensive treatment [anti-HTN]) in the Thessaloniki Eye Study (TES).
TES is a cross sectional population-based study of chronic eye diseases in subjects over 60 yrs in Thessaloniki, Greece. Among 2261 clinic-visits, 135 OAG cases were identified. Diastolic PP (DPP) and systolic PP (SPP) were calculated for all TES participants. Subjects were divided into 6 groups: low DPP ( less than 20th percentile) with (n=234) or without (n=214) anti-HTN, median DPP ( 20th-80th percentile) with (n=710) or without (n=640) anti-HTN, and high DPP ( more than 80th percentile) with (n=268) or without (n=185) anti-HTN. Subjects were similarly divided into 6 groups of SPP status respectfully. Percentages of OAG in groups were compared using logistic regression models with median DPP and median SPP without anti-HTN groups as references. Adjustments were made for age, gender and vascular factors identified as risk factors for OAG in a previous analysis (coronary artery bypass or vascular surgery and diabetes treated with insulin).
The 20th and 80th percentiles for DPP were 58.5mmHg and 79mmHg respectively; for SPP they were 110mmHg and 147.5mmHg respectively. Low DPP with anti-HTN group presented with statistically significantly higher odds for OAG compared to the reference group (Odds Ratio, 2.02, 95% Confidence Interval, 1.16 - 3.52, p=0.013). Low DPP without anti-HTN, high DPP with or without anti-HTN and median DPP with anti-HTN groups were not associated with OAG. SPP status was not associated with OAG.
This is the first study reporting that low DPP is associated with increased likelihood for OAG only in subjects receiving anti-HTN, while low DPP in subjects without anti-HTN is not associated with OAG.
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