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Mina Torres, Cathy Wu, Stanley Azen, Rohit Varma, LALES Group; Four-year Incidence of Open-angle Glaucoma (OAG) in a Population-Based Cohort of Adult Latinos: The Los Angeles Latino Eye Study (LALES). Invest. Ophthalmol. Vis. Sci. 2011;52(14):5032.
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To present the 4-year incidence of OAG in a population-based study of adult Latinos (primarily Mexican-American).
All participants underwent a complete eye examination by a trained ophthalmologist at baseline and 4-year follow-up, including a Humphrey Visual Field (SITA Standard), stereoscopic optic disc photography and Goldman applanation tonometry. Incident OAG was defined by the presence of having either characteristic optic nerve changes or visual field loss or both at follow-up in eyes where these changes were not present at baseline. Incidence in the first eye required that both eyes be free of disease at baseline; incidence of disease in the second eye required that, at baseline, one eye be free of disease while the contralateral eye has disease. Frequency procedures and chi-square tests were used to determine the distribution of incidence across age groups. All statistical testing was conducted at the 0.05 significance level, using SAS (SAS Institute, Cary, NC).
Of the 6100 living persons examined at baseline, 4658 were examined at the 4-year follow-up. Of the 4658, 3879 (83%) with complete data were included in this analysis. The 4-year incidence of OAG was 2.43% in the first eye among those with no OAG in either eye at baseline. Incidence of OAG increased significantly with age, from 0.97 % in 40-49 years old to 16.28% in those 80 years and older. In persons who had OAG in one eye at baseline, 13.98% developed OAG in the second eye at follow-up. There were no gender related differences.
This longitudinal study is the first to provide data on the incidence of OAG in Latinos. Incidence rates in Latinos are significantly higher than those observed in non-Hispanic Whites in Melbourne and Rotterdam but lower than African Caribbeans in Barbados. Physicians and patients should be aware of this 5-fold higher incidence of OAG in the second eye compared to the first eye.
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