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Shuang(Cathy) wu, Mina Torres, Rohit Varma, Los Angeles Latino Eye Study Group; Four-Year Incidence of Ocular Hypertension in Latinos: The Los Angeles Latino Eye Study (LALES). Invest. Ophthalmol. Vis. Sci. 2011;52(14):5044.
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To determine the 4-year incidence of Ocular Hypertension (OHT) in adult Latinos aged 40 years and older.
The Los Angeles Latino Eye Study is a longitudinal, population-based cohort study of urban Latinos aged 40 years and older. Participants underwent complete ophthalmologic examinations at baseline and at four years of follow-up, including measurement of intraocular pressure (IOP), visual field (VF) testing using an automated field analyzer, and simultaneous stereoscopic fundus photography of the optic disc. Ocular Hypertension was defined as IOP of ≥21 mmHg and the absence of optic disc damage or abnormal VF test results.
Of the 6100 participants examined at baseline, 4658 were examined at the 4-year follow-up. There were 121 incidence cases out of 3556 participants at risk. The 4-year incidence of OHT was 3.40% (95% CI, 2.80-4.00) in the first eye. No age-related increase was found in the incidence of OHT, with 2.27% (95% CI, 1.49-3.05) incidence rate for 40-49 years old participants and 2.86% (95% CI, 0-8.38) incidence rate for 80 years of age and older. In 96 persons who had OHT in one eye at baseline, 20 developed OHT in the second eye at follow-up. The 4-year incidence of OHT in the second eye was 20.83% (95% CI, 12.71-28.95).
These data provide the first population-based estimates of OHT in Latinos. Given that the incidence of OHT in the second eye is over 6 fold that in the first eye, physicians and persons with unilateral OHT should be aware of the high risk of developing OHT in the second eye.
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