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Ali Poostchi, Haogang Zhu, David P. Crabb, Stephen A. Vernon; Specificity Of HRT MRA And GPS Within The Bridlington Eye Assessment Project. Invest. Ophthalmol. Vis. Sci. 2011;52(14):5045.
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To determine the specificity of the Heidelberg Retina Tomography automated shape analysis tool (ASAT) in a normal elderly population.
6540 eyes of 3470 normal subjects (defined with fields and IOP) with a mean age 74 years, range 63 -99 years, from The Bridlington Eye Assessment Project (BEAP) were selected. Patients underwent optic nerve imaging using HRT 2 as well as a standard ophthalmic examination by trained optometrists. Scan data was imported into HRT3 for calculation of Moorfields Regression Analysis 3 (MRA3) and Glaucoma Probability Score (GPS), the internal ASAT. Subjects with a HRT mean pixel height standard deviation of greater than 68 um were excluded from the analysis.
When borderline cases were classified as abnormal, the specificities of GPS, Moorfields Regression Analysis 3 (MRA 3) and Clinical evaluation were 77 %, 83% and 94% respectively. This rose to 83% and 92 % for GPS and MRA when borderline cases were re-classified as normal.
When used in isolation, GPS is less specific than MRA3 or fundoscopy by trained optometrists when screening a population of normal elderly individuals.
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