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Cheryl S. Ngo, Carol Y. Chueng, Tien Y. Wong, Lei Huang, Seang-Mei Saw, Tin Aung; The Distribution of Inter-eye Asymmetry in Cup-to-disc Ratio in an Asian population: The Singapore Malay Eye Study. Invest. Ophthalmol. Vis. Sci. 2011;52(14):5058.
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To describe the distribution and factors of inter-eye asymmetry in vertical cup-to-disc ratio in an old general Asian population
The Singapore Malay Eye Study (SiMES) examined 3280 (78.7% response) persons aged 40-80 years between August 2004 and June 2006. Participants underwent a standardized interview, ophthalmic examination including measurement of central corneal thickness (CCT), intraocular pressure (IOP), anterior chamber depth (ACD) and axial length (AL). Vertical cup-to-disc ratio (CDR) was measured under slit-lamp by ophthalmologists. Inter-eye asymmetry was defined as the absolute CDR difference ≥ 0.2 between two eyes.
After excluding 74 persons with missing CDR data and 150 persons with glaucoma, 3056 were included in this analysis. Asymmetry in vertical CDR was found in 100 participants (3.27%). The mean absolute CDR difference was 0.03 (SD 0.18, range 0.00-1.00) in SiMES. In multivariate analyses, CDR asymmetry was independently associated with older age (odd ratio [OR] 1.04, 95% CI 1.02-1.06) and the presence of cataract (OR 3.23, 95% CI 2.09-4.97). AL, IOP, CCT and ACD were not found to be associated with asymmetry in vertical CDR in non-glaucomatous persons.
Asymmetric CDR was related to older age and presence of cataracts in this older non-glaucomatous Malay population.
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