Abstract
Purpose: :
To describe the distribution and factors of inter-eye asymmetry in vertical cup-to-disc ratio in an old general Asian population
Methods: :
The Singapore Malay Eye Study (SiMES) examined 3280 (78.7% response) persons aged 40-80 years between August 2004 and June 2006. Participants underwent a standardized interview, ophthalmic examination including measurement of central corneal thickness (CCT), intraocular pressure (IOP), anterior chamber depth (ACD) and axial length (AL). Vertical cup-to-disc ratio (CDR) was measured under slit-lamp by ophthalmologists. Inter-eye asymmetry was defined as the absolute CDR difference ≥ 0.2 between two eyes.
Results: :
After excluding 74 persons with missing CDR data and 150 persons with glaucoma, 3056 were included in this analysis. Asymmetry in vertical CDR was found in 100 participants (3.27%). The mean absolute CDR difference was 0.03 (SD 0.18, range 0.00-1.00) in SiMES. In multivariate analyses, CDR asymmetry was independently associated with older age (odd ratio [OR] 1.04, 95% CI 1.02-1.06) and the presence of cataract (OR 3.23, 95% CI 2.09-4.97). AL, IOP, CCT and ACD were not found to be associated with asymmetry in vertical CDR in non-glaucomatous persons.
Conclusions: :
Asymmetric CDR was related to older age and presence of cataracts in this older non-glaucomatous Malay population.