April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Structure-Function Relationships Are Linear in Early Glaucoma
Naveed Nilforushan; Kouros Nouri-Mahdavi; Nariman Nassiri; Dennis Mock; Anne Coleman; Simon Law; JoAnn Giaconi; Joseph Caprioli
Author Affiliations & Notes
  • Naveed Nilforushan
    Ophthalmology, UCLA, Jules-Stein Eye Institiute, Los Angeles, California
  • Kouros Nouri-Mahdavi
    Ophthalmology, UCLA, Jules-Stein Eye Institiute, Los Angeles, California
  • Nariman Nassiri
    Ophthalmology, UCLA, Jules-Stein Eye Institiute, Los Angeles, California
  • Dennis Mock
    Ophthalmology, UCLA, Jules-Stein Eye Institiute, Los Angeles, California
  • Anne Coleman
    Ophthalmology, UCLA, Jules-Stein Eye Institiute, Los Angeles, California
  • Simon Law
    Ophthalmology, UCLA, Jules-Stein Eye Institiute, Los Angeles, California
  • JoAnn Giaconi
    Ophthalmology, UCLA, Jules-Stein Eye Institiute, Los Angeles, California
  • Joseph Caprioli
    Ophthalmology, UCLA, Jules-Stein Eye Institiute, Los Angeles, California
  • Footnotes
    Commercial Relationships  Naveed Nilforushan, None; Kouros Nouri-Mahdavi, Allergan C (C, R); Nariman Nassiri, None; Dennis Mock, None; Anne Coleman, None; Simon Law, None; JoAnn Giaconi, None; Joseph Caprioli, Allergan C, Pfizer S, Alcon S (C, R)
  • Footnotes
    Support  Partially supported by an unrestricted grant from Research to Prevent Blindness
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 5084. doi:
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      Naveed Nilforushan, Kouros Nouri-Mahdavi, Nariman Nassiri, Dennis Mock, Anne Coleman, Simon Law, JoAnn Giaconi, Joseph Caprioli; Structure-Function Relationships Are Linear in Early Glaucoma. Invest. Ophthalmol. Vis. Sci. 2011;52(14):5084.

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Abstract

Purpose: : To explore whether structure-function relationships, as evaluated with retinal nerve fiber layer (RNFL) thickness measurement and achromatic visual fields or short wavelength automated perimetry (SWAP), can be detected in early glaucoma.

Methods: : One-hundred eighteen eyes of 78 patients with early or suspected glaucoma were selected from the clinical database at UCLA’s Glaucoma Division. All patients had a spectral-domain optical coherence tomography (SD-OCT) RNFL image (optic disc cube 200x200, Cirrus OCT, Carl Zeiss Meditec, Inc) and a reliable 24-2 SITA-Standard (Group A: MD better than -5.0 dB; 73 eyes) or SWAP (Group B: 45 eyes) Humphrey visual field within a 6-month period. The OCT images were required to be well focused, have a signal strength more than or equal to 7 and average RNFL thickness more than or equal to 80 microns. Canonical correlation analyses were used to determine the correlation between the average RNFL thickness in 10-degree OCT sectors on the OCT’s circumpapillary measurement circle (diameter 3.46 mm) and 52 individual visual field locations (excluding points above and below the blind spot) grouped in 4 main regions (superior, inferior, temporal, and central clusters). The correlation between the first canonical coefficients from the structural and functional measures was the main outcome measure.

Results: : The average RNFL thickness was 88.6 ± 5.7 and 88.6 ± 4.9 microns in Group A and B, respectively. The average mean deviation was -1.0 ± 1.7 dB in Group A and -0.61 ± 3.4 dB in Group B. All the first canonical coefficients for the correlations between inferior, superior, central, and temporal regions of the visual field vs. corresponding regions of the RNFL were significant for both groups (Rc = 0.81, 0.81, 0.57, and 0.52 in Group A and Rc = 0.91, 0.98, 0.71, and 0.74, respectively in Group B; p <0.001 for all). The structure-function relationship between the corresponding regions of visual field and peripapillary RNFL was mostly linear.

Conclusions: : Structure-function relationships seem to be linear in early glaucoma and can be detected if more localized measures of RNFL or visual field are employed.

Keywords: visual fields • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • optic disc 
© 2011, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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