April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
A Pilot Study to Provide Proof of Concept of a Novel Monochromatic Sub-Pixel Strategy for the Moorfields Motion Displacement Test (MMDT)
Author Affiliations & Notes
  • Zaman K. Durani
    St George's University of London, London, United Kingdom
  • Gay M. Verdon-Roe
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
  • Ciara Bergin
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
  • Rizwan Malik
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
  • Fred W. Fitzke
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
  • Ananth C. Viswanathan
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
  • Mark C. Westcott
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
  • David P. Crabb
    Optometry and Visual Science, City University London, London, United Kingdom
  • David F. Garway-Heath
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
  • Footnotes
    Commercial Relationships  Zaman K. Durani, None; Gay M. Verdon-Roe, Moorfields MDT (P), Pfizer (F); Ciara Bergin, Moorfields MDT (P); Rizwan Malik, None; Fred W. Fitzke, Moorfields MDT (P); Ananth C. Viswanathan, Moorfields MDT (P); Mark C. Westcott, Moorfields MDT (P); David P. Crabb, Moorfields MDT (P); David F. Garway-Heath, Carl Zeiss Meditec (R), Carl Zeiss Meditec; Heidelberg Engineering; (F), Moorfields MDT (P)
  • Footnotes
    Support  The Special Trustees of Moorfields Eye Hospital; Pfizer Inc; NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London.
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 5512. doi:https://doi.org/
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      Zaman K. Durani, Gay M. Verdon-Roe, Ciara Bergin, Rizwan Malik, Fred W. Fitzke, Ananth C. Viswanathan, Mark C. Westcott, David P. Crabb, David F. Garway-Heath; A Pilot Study to Provide Proof of Concept of a Novel Monochromatic Sub-Pixel Strategy for the Moorfields Motion Displacement Test (MMDT). Invest. Ophthalmol. Vis. Sci. 2011;52(14):5512. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

The pixel size of standard LCD monitors limits the resolution of the hyperacuity Moorfields Motion Displacement Test (MMDT) to measure thresholds in young subjects. This study was designed to provide proof of concept of a novel sub-pixel displacement strategy for the purpose of increasing the MMDT dynamic test range.

 
Methods:
 

The MMDT 32-location test was presented on an EIZO GS521 monochromatic monitor (0.165mm pitch). The right eye of two healthy subjects (aged 25 and 20 years) was tested. Frequency of seeing (FOS) curves were generated at 9 locations for whole and sub-pixel motion displacements using a multi-location FOS test strategy. 15 presentations were made for each increment of displacement. FOS curves were generated and 95% confidence intervals (CI) compared between the two strategies (Wilcoxon test; SPSS version 16; log10 probit fit).

 
Results:
 

The sub-pixel strategy extended the lower end of the MMDT dynamic test range at locations where responses at the smallest whole pixel displacement were seen. The finer increments of displacement provided by the sub-pixel strategy significantly narrowed the CIs (P < 0.01). The mean reduction for the 95% CI at the 50% threshold for the two central locations was 23%.

 
Conclusions:
 

The MMDT sub-pixel strategy increases the lower end of the dynamic test range of the MMDT so that thresholds can now be measured across all locations. The greater sampling provided by sub-pixellation means that the role of the MMDT may be extended to threshold testing and monitoring of glaucoma.  

 
Keywords: visual fields • perimetry 
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