April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Development Of A Multi-attribute Instrument For Estimating Of Utilities In People With Glaucoma
Author Affiliations & Notes
  • Steven M. Kymes
    Ophthal/Vis Science, Washington Univ Sch of Med, St Louis, Missouri
    Center for Economic Evaluation in Medicine, St. Louis, Missouri
  • Colleen M. Peters
    Ophthal/Vis Science, Washington Univ Sch of Med, St Louis, Missouri
    Center for Economic Evaluation in Medicine, St. Louis, Missouri
  • Kathleen M. Beusterien
    Oxford Outcomes, Washington, Dist. of Columbia
  • Sameer Kotak
    Ophthalmology, Pfizer, New York, New York
  • Dustin L. Stwalley
    Ophthal/Vis Science, Washington Univ Sch of Med, St Louis, Missouri
    Center for Economic Evaluation in Medicine, St. Louis, Missouri
  • Andreas M. Pleil
    Worldwide Med & Outcomes Rsch, Pfizer Inc, San Diego, California
  • Footnotes
    Commercial Relationships  Steven M. Kymes, Genentech (F), Pfizer, Inc. (F); Colleen M. Peters, Genentech (F), Pfizer, Inc. (F); Kathleen M. Beusterien, Oxford Outcomes (F); Sameer Kotak, Pfizer, Inc. (F); Dustin L. Stwalley, Genentech (F), Pfizer, Inc. (F); Andreas M. Pleil, Pfizer, Inc. (F)
  • Footnotes
    Support  Support for this project was provided by grants from Pfizer, Inc and Prevent Blindness America, The Department of Ophthalmology and Visual Sciences benefits from an unrestricted grant from Research t
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 5530. doi:
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      Steven M. Kymes, Colleen M. Peters, Kathleen M. Beusterien, Sameer Kotak, Dustin L. Stwalley, Andreas M. Pleil; Development Of A Multi-attribute Instrument For Estimating Of Utilities In People With Glaucoma. Invest. Ophthalmol. Vis. Sci. 2011;52(14):5530.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

We developed a short interview based upon the National Eye Institute’s Visual Function Questionnaire (NEI-VFQ) to estimate utility loss from POAG progression.

 
Methods:
 

We identified items from the NEI-VFQ responsive to differences in mean deviation in a cross sectional sample of 1,677 people enrolled in OHTS and 99 people with more advanced disease. Twelve items were identified and incorporated into a conjoint interview administered to 48 people with POAG. From these results we identified 5 items of greatest importance (the peripheral vision item was added separately). We then constructed an interview using standard gamble and visual analog scale which was administered to 404 community based participants to elicit utlility weights for these items.

 
Results:
 

The five attributes most important to people with glaucoma were reading, driving, leaving home, requiring help with activities and the ability to accomplish tasks. Loss of all of these functions and peripheral vision had a disutilty of 0.27. In the Table we detail the utility loss associated with each item.

 
Conclusions:
 

There is measurable loss of utility associated with modest loss in visual function. However, determining how this is associated with glaucoma progression remains to be seen and will be part of our validation of the instrument.  

 
Keywords: clinical (human) or epidemiologic studies: systems/equipment/techniques • intraocular pressure 
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