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Ruwan A. Silva, Charles C. Wykoff, Darlene Miller, Harry W. Flynn, Jr.; Spectrum Of Fungal Isolates In Culture Proven Exogenous Fungal Endophthalmitis. Invest. Ophthalmol. Vis. Sci. 2011;52(14):5613.
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To report the fungal species isolated from ocular specimens in a large series of patients with exogenous fungal endophthalmitis.
Retrospective, single institution, consecutive case series. The microbiologic and medical records of all patients treated at the Bascom Palmer Eye Institute between January 1, 1990, and June 30, 2010, for culture-proven exogenous fungal endophthalmitis were reviewed.
Culture-positive exogenous fungal endophthalmitis occurred in 72 eyes, including 29 cases (40%) associated with fungal keratitis and 33 cases (46%) occurring after penetrating ocular trauma or intraocular surgery. Filamentous fungi (molds) accounted for 55 cases (76%), and Candida species (yeasts) accounted for 17 cases (24%). Although most keratitis cases were caused by Fusarium (19 of 29; 66%), open-globe cases were caused by a broader spectrum of fungi.
This report highlights the differences between the clinical categories of exogenous fungal endophthalmitis. Although 76% of all cases were caused by molds, most commonly Fusarium and Aspergillus, the most common fungal species varied by clinical category.
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