April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Measurement of Retinal Oxygen Saturation in Patients with Chronic Obstructive Pulmonary Disease
Author Affiliations & Notes
  • Stefan Palkovits
    Department of Clinical Pharmacology,
    Medical University of Vienna, Vienna, Austria
  • Michael Lasta
    Department of Clinical Pharmacology,
    Medical University of Vienna, Vienna, Austria
  • Doreen Schmidl
    Department of Clinical Pharmacology,
    Medical University of Vienna, Vienna, Austria
  • Agnes Boltz
    Department of Clinical Pharmacology,
    Medical University of Vienna, Vienna, Austria
  • Semira Kaya
    Department of Clinical Pharmacology,
    Medical University of Vienna, Vienna, Austria
  • Gerhard Garhofer
    Department of Clinical Pharmacology,
    Medical University of Vienna, Vienna, Austria
  • Leopold Schmetterer
    Department of Clinical Pharmacology,
    Center for Medical Physics and Biomedical Engineering,
    Medical University of Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships  Stefan Palkovits, None; Michael Lasta, None; Doreen Schmidl, None; Agnes Boltz, None; Semira Kaya, None; Gerhard Garhofer, None; Leopold Schmetterer, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 5647. doi:
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      Stefan Palkovits, Michael Lasta, Doreen Schmidl, Agnes Boltz, Semira Kaya, Gerhard Garhofer, Leopold Schmetterer; Measurement of Retinal Oxygen Saturation in Patients with Chronic Obstructive Pulmonary Disease. Invest. Ophthalmol. Vis. Sci. 2011;52(14):5647.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : In the recent years several systems for the measurement of retinal oxygen saturation became commercially available. These systems rely on spectral analysis of the light reflected and scattered at the fundus. To measure the validity of the obtained results is, however, difficult, because no gold standard method for the measurement of retinal oxygen saturation exists. We measured oxygen saturation in patients with reduced arterial oxygen saturation due to pulmonary disease and compared data obtained in retinal arteries with systemic oxygen saturation.

Methods: : Seven patients with chronic obstructive pulmonary disease were included in this study. Retinal arterial and venous oxygen saturation was studied using spectral analysis of fundus photos using a color CCD camera (Retinal Vessel Analyzer, Imedos, Jena, Germany). Systemic oxygen saturation was studied using a pulse oximeter.

Results: : Systemic oxygen saturation in patients with COPD was 86.7 ± 3.7 %. Retinal arterial and venous oxygen saturation was 83.4 ± 5.4 % and 45.3 ± 6.9 %, respectively. The correlation between systemic oxygen saturation and retinal arterial oxygen saturation was high (r = 0.81, P = 0.024).

Conclusions: : Our data indicate that measurements of arterial retinal oxygen saturation using the Retinal Vessel Analyzer show adequate validity. Further studies in larger study populations of patients with pulmonary disease are required to support this conclusion.

Clinical Trial: : http://www.clinicaltrials.gov NCT00999024

Keywords: oxygen • hypoxia • retina 
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