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Stefan Palkovits, Michael Lasta, Doreen Schmidl, Agnes Boltz, Semira Kaya, Gerhard Garhofer, Leopold Schmetterer; Measurement of Retinal Oxygen Saturation in Patients with Chronic Obstructive Pulmonary Disease. Invest. Ophthalmol. Vis. Sci. 2011;52(14):5647.
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In the recent years several systems for the measurement of retinal oxygen saturation became commercially available. These systems rely on spectral analysis of the light reflected and scattered at the fundus. To measure the validity of the obtained results is, however, difficult, because no gold standard method for the measurement of retinal oxygen saturation exists. We measured oxygen saturation in patients with reduced arterial oxygen saturation due to pulmonary disease and compared data obtained in retinal arteries with systemic oxygen saturation.
Seven patients with chronic obstructive pulmonary disease were included in this study. Retinal arterial and venous oxygen saturation was studied using spectral analysis of fundus photos using a color CCD camera (Retinal Vessel Analyzer, Imedos, Jena, Germany). Systemic oxygen saturation was studied using a pulse oximeter.
Systemic oxygen saturation in patients with COPD was 86.7 ± 3.7 %. Retinal arterial and venous oxygen saturation was 83.4 ± 5.4 % and 45.3 ± 6.9 %, respectively. The correlation between systemic oxygen saturation and retinal arterial oxygen saturation was high (r = 0.81, P = 0.024).
Our data indicate that measurements of arterial retinal oxygen saturation using the Retinal Vessel Analyzer show adequate validity. Further studies in larger study populations of patients with pulmonary disease are required to support this conclusion.
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