Purchase this article with an account.
Denise S. Ryan, Kraig S. Bower, Charles D. Coe, Rose K. Sia, Lamarr Peppers, Richard D. Stutzman, Shachar Tauber, Scheffer C. Tseng; Sutureless Cryopreserved Amniotic Membrane Graft (ProKeraTM) vs. Bandage Contact Lens (BCL): Comparing Optical Quality of the Cornea After Photorefractive Keratectomy (PRK). Invest. Ophthalmol. Vis. Sci. 2011;52(14):5741.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To compare optical quality of ProKera vs. BCL after PRK in terms of corneal surface regularity and corneal haze.
Forty subjects undergoing PRK at the Walter Reed Center for Refractive Surgery were enrolled in a prospective, open-label, non-randomized, controlled trial. Standard 9.0 mm epithelial defects were created using a 20% ethanol solution followed by photoablation using the ALLEGRETO WAVE Eye-Q 400 MHz laser platform (Wavelight AG, Erlangen, Germany). ProKera was applied on the non-dominant eye after surgery and a high oxygen transmissible BCL on the dominant eye. The following TMS-4 corneal topography (Tomey, Phoenix, AZ) indices were used to assess optical quality: surface asymmetry index (SAI), surface regularity index (SRI), and irregular astigmatism index (IAI). Corneal haze was also assessed at 1 week (W), 2W, 1, 3, 6, and 12 months (M) postoperatively. A Wilcoxon signed ranks test was used to compare ProKera to BCL and a P value <0.007 was considered significant, adjusting for multiple comparisons across 7 time points.
Median topography indices of ProKera vs. BCL are listed on Table 1. There was no significant difference between ProKera vs. BCL in measures of SRI or IAI. There was a significant difference in SAI at 1 month between ProKera and BCL, but not at any other time point. At 1M, 9 more ProKera eyes had haze than BCL eyes (P=0.002). The difference in corneal haze was not significant at other visits 1W(P= 0.99), 2W(P=0.99), 3M(P=0.25), 6M(P=0.25), 12M(P=0.50).
ProKera was comparable to BCL when investigating corneal clarity and quality of vision. The role of ProKera in modulating wound healing after PRK remains speculative.
This PDF is available to Subscribers Only