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Eun Jung Jun, Jin Hyoung Kim, Nikki Camara, Tracy L. Purcell, David J. Schanzlin; The Comparison Of Ocular Rigidity Changes After Intacs Implantation, Corneal Collagen Cross Linking, And Combined Treatment. Invest. Ophthalmol. Vis. Sci. 2011;52(14):5771.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the ocular rigidity and K reading changes which may occur between globes before and after treatment of Intacs implantation, corneal collagen cross linking, and the combined treatment of Intacs and corneal collagen cross linking.
We obtained 15 research-grade whole globes from the San Diego Eye Bank. We used 5 globes for Intacs implantation, size 0.25mm (Group I), 5 globes for corneal collagen cross-linking (Group II), and 5 globes for combined treatment of Intacs implantation and corneal collagen cross-linking (Group III). In corneal cross linking procedure, riboflavin 0.1% solution was applied every 2 minutes for 30 minutes and every 5 minutes during irradiation for 30 total minutes. We measured ocular rigidity using Friedenwald nomogram and K value readings using Pentacam before and after the procedure.
The mean ocular rigidity change was 0.0102±0.00148 (Mean±SD) in Group I, 0.086±0.00114 in Group II, and 0.0124±0.00134 in Group III, respectively. From our study we found that ocular rigidity was increased in each group and there was a significant increase in Group III, the combined treatment group, compared to Group II (P=0.02). The mean K was decreased after treatment in each group but there were no significant differences between each group.
The outcome of the combination treatment was more effective in ocular rigidity change than corneal collagen cross-linking only treatment (P=0.02). Although further studies are needed, combined treatment may be an effective option for keratoconus.
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