April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
The Effect Of Statins On Ocular Microcirculation In Patients With Hypercholesterolemia
Author Affiliations & Notes
  • Naim Terai
    Ophthalmology,
    University of Dresden, Dresden, Germany
  • Eberhard Spoerl
    Ophthalmology,
    University of Dresden, Dresden, Germany
  • Sabine Fischer
    Internal Medicine,
    University of Dresden, Dresden, Germany
  • Karin R. Hornykewycz
    Dept of Ophthalmology, Univ Clinic Carl Gustav Carus Dresden, Dresden, Germany
  • Michael Haustein
    Ophthalmology,
    University of Dresden, Dresden, Germany
  • Janek Haentzschel
    Ophthalmology,
    University of Dresden, Dresden, Germany
  • Lutz E. Pillunat
    Ophthalmology,
    University of Dresden, Dresden, Germany
  • Footnotes
    Commercial Relationships  Naim Terai, None; Eberhard Spoerl, None; Sabine Fischer, None; Karin R. Hornykewycz, None; Michael Haustein, None; Janek Haentzschel, None; Lutz E. Pillunat, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 6051. doi:
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      Naim Terai, Eberhard Spoerl, Sabine Fischer, Karin R. Hornykewycz, Michael Haustein, Janek Haentzschel, Lutz E. Pillunat; The Effect Of Statins On Ocular Microcirculation In Patients With Hypercholesterolemia. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6051.

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Abstract

Purpose: : To investigate the effect of statins on ocular microcirculation in patients with hypercholesterolemia

Methods: : Ten patients with hypercholesterolemia were included in this study. The diameter of retinal vessels was measured continuously with the retinal vessel analyzer (RVA) before and 4 weeks after statin therapy. After baseline assessment a monochromatic luminance flicker was applied to evoke retinal vasodilation. Flicker response was then analyzed 50, 70 and 120 sec after baseline measurement. Additionally, cholesterol-, HDL-, LDL- and triglyceride level were obtained to find a possible correlation between retinal vessel diameter changes and lipid metabolism before and after statin therapy.

Results: : The mean diameter of the arterioles before statin therapy at baseline was 106.3±1.5 µm and the mean diameter of the venules at baseline was 127.3±2.5µm. The mean diameter of the arterioles 4 weeks after statin therapy at baseline was 107.1±1.6µm and the mean diameter of the venules at baseline was 127.7±2.3µm which was significantly different from measurements before statin therapy (P=0.004). The diameter of the arterioles 4 weeks after statin therapy increased to 109.2±2.1 µm after 50 sec, to 110.6±2.6 µm after 70 sec and to 111.8±2.3µm after 120 sec with statistical significance at all time points (P=0.001). The mean diameter of the venules after statin therapy increased to 130.6±2.7µm after 50 sec, to 132.1±2.6µm after 70 sec and to 133.5±3.0µm after 120 sec with statistical significance at all time points (P=0.001).

Conclusions: : The present study demonstrated a significant increase in vasodilatation of retinal arterioles and venules 4 weeks after statin therapy in patients with hypercholesterolemia. This effect might be elicited by an endothelium-dependent NO-mediated vasodilatation, indicating a beneficial effect of statins on vasomotoric response in retinal vessels which is seen beyond the cholesterol lowering effect.

Keywords: optic disc • imaging/image analysis: clinical • nitric oxide 
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