April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Electroretinography And Optical Coherence Tomography In Patients With Age Related Macular Degeneration Before, During, And After Treatment With Ranibizumab
Author Affiliations & Notes
  • Izabela N. Frota de Almeida
    Nucleo de Medicina Tropical,
    Instituto de Ciencias da Saude,
    Universidade Federal do Para, Belem, Brazil
  • Luciana N. Frota de Almeida
    Hospital Sao Geraldo, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
  • Edmundo Frota de Almeida Sobrinho
    Instituto de Ciencias da Saude,
    Hospital Universitario Bettina Ferro de Souza,
    Universidade Federal do Para, Belem, Brazil
  • Givago S. Souza
    Nucleo de Medicina Tropical,
    Instituto de Ciencias Biologicas,
    Universidade Federal do Para, Belem, Brazil
  • Bruno D. Gomes
    Instituto de Ciencias Biologicas,
    Universidade Federal do Para, Belem, Brazil
  • Alexandre M. Rosa
    Instituto de Ciencias da Saude,
    Hospital Universitario Bettina Ferro de Souza,
    Universidade Federal do Para, Belem, Brazil
  • Luiz Carlos L. Silveira
    Nucleo de Medicina Tropical,
    Instituto de Ciencias Biologicas,
    Universidade Federal do Para, Belem, Brazil
  • Footnotes
    Commercial Relationships  Izabela N. Frota de Almeida, None; Luciana N. Frota de Almeida, None; Edmundo Frota de Almeida Sobrinho, None; Givago S. Souza, None; Bruno D. Gomes, None; Alexandre M. Rosa, None; Luiz Carlos L. Silveira, None
  • Footnotes
    Support  FINEP IBN Net, CNPq-PRONEX / FAPESPA; UFPA-PIBEX; CNPq; CAPES; LCLS is a CNPq research fellow
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 6071. doi:
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      Izabela N. Frota de Almeida, Luciana N. Frota de Almeida, Edmundo Frota de Almeida Sobrinho, Givago S. Souza, Bruno D. Gomes, Alexandre M. Rosa, Luiz Carlos L. Silveira; Electroretinography And Optical Coherence Tomography In Patients With Age Related Macular Degeneration Before, During, And After Treatment With Ranibizumab. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6071.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate retinal morphology and electrophysiology of patients with choroidal neovascular membrane (CNV), secondary to age-related macular degeneration (AMD), before, during, and after treatment with ranibizumab.

Methods: : Sixteen patients, 71.2 ± 9.9 years old, diagnosed with CNV secondary to AMD in one or both eyes were studied with optical coherence tomography (Stratus OCT), multifocal (mfERG-103 hexagons protocol) and full field electroretinography (ffERG; scotopic and photopic protocols) (VERIS). Intravitreal injections of 0.05 ml anti-angiogenic ranibizumab were administered at 1 month intervals between each injection over a 3 month period. OCT, mfERG, and ffERG were performed before the first injection (D0) and at 1, 2, and 3 months after each injection (D30, D60, and D90).

Results: : Twenty-two eyes were tested. Visual acuity was 1.64 ± 0.72 logMAR. OCT performed before treatment showed increased thickness of retinal inner layers in the macula due to intraretinal fluid and increased thickness of the retinal pigment epithelium-choriocapillaris complex (RPE-CC) related to CNV. Follow-up OCT examination showed reduction of intraretinal oedema but persistence of RPE-CC complex increased thickness, forming a subretinal scar in the fovea and inner macula (p < 0.05, ANOVA one way, Tukey test). mfERG amplitude response had not recovered at the macula after treatment. ffERG photopic amplitude and implicit time had no statistical difference after the treatment, but scotopic ERG b-wave implicit time was longer after the treatment than before (p < 0.05).

Conclusions: : The results suggest that ranibizumab decreases retinal oedema as observed by OCT, but it does not seem to recovery retinal function as evaluated by the mfERG and ffERG.

Keywords: age-related macular degeneration • electroretinography: clinical • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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