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Keiko Momose; Kernel of VEP Elicited by Pseudorandom Stimulation with the Swept Parameter Technique and Their Correlation with Magno- and Parvocellular Pathway Responses. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6091.
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To determine whether our previously suggested method1 is valid and effective to extract magnocellular (M) and parvocellular (P) components from VEP. The method employed the pseudorandom binary sequence (PRBS) stimulation combined with swept parameter technique to elicit VEP and the nonlinear system identification method for analysis.
VEP elicited by luminance modulated sinusoidal gratings based on PRBS was recorded and their second-order kernels were calculated as cross-correlation between PRBS and VEP. To manipulate the magnitudes of M and P visual pathway responses in VEP, the spatial frequency of gratings were swept during the PRBS stimulation. VEP to this stimulation was recorded from 5 healthy participants and their binary kernels changes during the stimulation were evaluated. PRBS stimulation of 40950 ms period was repeated twice, and the spatial frequency was swept from 0.1 to 5 c/deg or 5 to 0.1 c/deg within the period.
The waveforms around 80-300 ms of second kernels were continuously changed and the latency of peaks in 80-200 ms extended during the stimulation. Waveforms of the kernels obtained from the former and latter half of the PRBS stimulation showed different features and they were similar to those in previous studies2,3 which presented the relationship between M/P pathway responses and waveform of kernels obtained from conventional VEP measurement. The changes may reflect the M and P pathway contribution changes during the stimulation and depend on the spatial frequency sweeping.
The suggested technique would be effective for studying and screening several eye and neuro-cognitive disorders which have been reported to relate with selective damage in M/P pathways.Reference 1. Momose K, Proc. 31th Annu. Conf. the IEEE EMBS (CD-ROM), 2010: 6571-6574.2. A. Klistorner, D.P. Crewther, S.G. Crewther, Vision Res 37, 1997: 2161-2169.3. H.A. Baseler, E.E. Sutter, Vision Res 37, 1997: 675-690.
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